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Safety review initiated following post-surgical fatalities in ultra-rapid metabolisers
Do not use in children aged 16 years or less, except in specialist settings under expert medical supervision.
New simplified guidance on treating paracetamol overdose with intravenous acetylcysteine including an updated treatment nomogram.
New maximum single intravenous dose of ondansetron for the management of chemotherapy-induced nausea and vomiting (CINV) restricted due to risk of QTc prolongation.
False blood glucose readings when used to flush arterial lines leading to incorrect insulin administration and potentially fatal hypoglycaemia.
The Food and Drug Administration (FDA) has received 35 reports of chondrolysis involving patients given continuous intra-articular infusions of local anaesthetics.
Patients with existing meningioma or a history of meningioma must not be prescribed high-dose (≥25 mg per day) cyproterone acetate.
Continued monitoring of medicines with a black triangle status.
Toxic effects can occur with nitrous oxide especially with prolonged use.
Updated guidance on the supply and administration of Botox, Vistabel, Dysport, and other injectable medicines used in cosmetic procedures.
To avoid the risk of air embolism, these products should not be infused under pressure.
Risk of early psychiatric side-effects is one of several important safety issues for healthcare professionals to discuss with patients and carers, who should seek urgent medical advice in the event of any worrying symptoms.
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