News story

Delgocitinib approved to treat adult patients with moderate to severe chronic hand eczema

The Medicines and Healthcare products Regulatory Agency has approved the medicine delgocitinib (Anzupgo) to treat moderate to severe chronic hand eczema in adults when topical corticosteroids are inadequate or inappropriate.

From:
Medicines and Healthcare products Regulatory Agency
Published
10 December 2024
Last updated
10 December 2024 — See all updates

Chronic hand eczema is an inflammatory skin condition that causes symptoms such as itching and pain.

Anzupgo contains the active substance delgocitinib, which belongs to a group of medicines called Janus kinase inhibitors.

Delgocitinib works by blocking the activity of four specific Janus kinase enzymes, which helps reduce inflammation and immune responses that cause hand eczema. By suppressing these processes, delgocitinib can help to  reduce inflammation of the skin, itching and pain. This, in turn, can increase the ability to perform daily activities and can improve the quality of life.

As with any medicine, the MHRA will keep the safety and effectiveness of delgocitinib under close review. Anyone who suspects they are having a side effect from this medicine are encouraged to talk to their doctor, pharmacist or nurse and report it directly to the Yellow Card scheme, either through the website (https://yellowcard.mhra.gov.uk/) or by searching the Google Play or Apple App stores for MHRA Yellow Card.

ENDS

Notes to editors 

  1. The new marketing authorisation was granted in 59 days on 29 November 2024 to Leo Pharma AS under the International Recognition Procedure (IRP) Route B.
  2. The Reference Regulator (RR) was the European Medicines Agency (EMA), with the procedure number (EMEA/H/C/006109/0000).
  3. More information can be found in the Summary of Product Characteristics and Patient Information leaflets which will be published on the MHRA Products website within 7 days of approval. 
  4. The Medicines and Healthcare products Regulatory Agency (MHRA) is responsible for regulating all medicines and medical devices in the UK by ensuring they work and are acceptably safe.  All our work is underpinned by robust and fact-based judgements to ensure that the benefits justify any risks. 
  5. The MHRA is an executive agency of the Department of Health and Social Care. 
  6. For media enquiries, please contact the newscentre@mhra.gov.uk, or call on 020 3080 7651.

Updates to this page

Published 10 December 2024
Last updated 10 December 2024 + show all updates

  1. Changed to amend headline from 'severe eczema' to 'moderate to severe' eczema

  2. First published.