Membership
Membership and minutes for the Commission on Human Medicines (CHM) and its expert advisory groups (EAGs).
Working for us
In the public interest, ministers need the advice they receive on matters relating to the regulation of medicines and medical devices to be impartial. They also need to be able to get advice from a wide range of highly-skilled professionals who are senior and well regarded in their respective fields and from a range of appointed lay representatives.
A number of independent advisory committees have been established to provide this advice. These committees can also establish working groups to address specific problems. Members of these committees may receive a fee and can claim some expenses.
If you are interested in being part of the Commission on Human Medicines or one of its expert advisory groups please contact cstrecruitment@mhra.gov.uk.
The chair and commissioners are appointed in accordance with the Code of Practice for Ministerial Appointments to Public Bodies, issued by the Commissioner for Public Appointments. The chair and commissioners follow a code of practice, in which they are precluded from holding personal interests. Their interests in the pharmaceutical industry are published in the commission’s annual report each year.
The commission meets monthly in London. The commission is supported in its work by expert advisory groups (EAGs), covering various areas of medicine. In addition, the commission calls on experts not readily available through its membership.
Current vacancies
The CHM Expert Advisory Group is looking to appoint one expert member to the Paediatric Medicines Expert Advisory Group (PMEAG) in the following area;
General Paediatrician
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Application Form (PDF, 154 KB, 9 pages)
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Diversity Monitoring Form (PDF, 164 KB, 3 pages)
The closing date for applications is Friday 31 January 2025.
The CHM Expert Advisory Group is looking to looking to appoint an expert to the Neurology, Pain and Psychiatry Expert Advisory Group (NPP EAG) in the following area;
Neurology and dementia
- Application Form (PDF, 154 KB, 9 pages)
- Diversity Monitoring Form (PDF, 164 KB, 3 pages)
- Declaration of Interests Form
The closing date for applications is Friday 10 January 2025.
CHM chair and commissioners
(Chair) Professor Sir Munir Pirmohamed MB ChB (Hons) PhD FRCP FRCP (Edin) FBPhS, FFPM (Hon) FMedSci, David Weatherall Chair of Medicine, University of Liverpool, NHS Chair of Pharmacogenetics, Director of the Wolfson Centre for Personalised Medicine, Director of the Centre for Drug Safety Science
Professor Amanda Adler MD PhD FRCP Professor of Diabetic Medicine and Health Policy, University of Oxford
Professor Jamie Coleman MD MA (Med Ed) FRCP FBPhS Professor in Medical Education / Consultant Clinical Pharmacologist, University of Birmingham
Professor Steven Cunningham MBChB PhD FRCPCH Professor of Paediatric Respiratory Medicine, University of Edinburgh and Honorary Consultant, Royal Hospital for Children and Young People, NHS Lothian, Edinburgh
Dr Jamie Fraser BSc (Hons) MBChB MRCGP GP Partner, Southside Surgery, Inverness
Professor Sandosh Padmanabhan MBBS MD PhD FRCP(Glasg) FRCP(Edin) FBPhS FBIHS Professor of Cardiovascular Genomics and Therapeutics, University of Glasgow
Professor Poulam Patel PhD, MBBS, FRCP Professor of Clinical Oncology, University of Nottingham
Professor Yvonne Perrie BSc Hons MRPharmS FAPS FSB PhD Chair in Drug Delivery, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow. Scotland
Professor Marc Turner MBChB PhD MBA FRCP FRCPath FRSE Professor of Cellular Therapy; Director Scottish National Blood Transfusion Service (SNBTS)
Professor Christopher Weir BSc (Hons) PhD MSc FRSS C.Stat
Personal Chair in Medical Statistics and Clinical Trials, Usher Institute, University of Edinburgh
Dr Martin Wilson MRCP (UK) MPhil (Glasgow), FRCP(Edin) Consultant Physician in Care of the Elderly, Raigmore Hospital, Inverness
Mrs Julia Cons Lay Representative
Professor Paul I Dargan MB BS FRCP Edin FACMT FRCP ERT FAACT FEAPCCT FBPhS MAE Consultant Physician and Professor of Clinical Toxicology, Guy’s and St Thomas’ NHS Foundation Trust, London Professor of Clinical Toxicology, King’s College London
Professor David Dockrell MB BCh MD FRCPI FRCP (Glas) FACP Professor of Infection Medicine, University of Edinburgh
Professor David Hunt MB BChir FRCP PhD Consultant Neurologist, NHS Lothian, Professor of Neuroinflammatory Medicine, University of Edinburgh
Dr Gerri Mortimore PhD; MSc Advanced Practice; PgCert (IPPE); Ba(Hons) Health Studies; iLM. RGN; NMP; FHEA Associate Professor in Advanced Clinical Practice; NICE Nurse Expert Advisor
Professor Vanessa Raymont MBChB MSc MRCPsych Associate Professor, University of Oxford and Honorary Consultant Psychiatrist, Oxford Health NHS Foundation Trust
Professor Anthony Williams BSc MSc MRCP, FRCPath, PhD Professor of Translational Medicine and Honorary Consultant in Clinical Immunology and Allergy, University of Southampton and University Hospital Southampton NHS Trust
Professor Rui Providencia MD PhD Consultant Cardiologist & Cardiac Electrophysiologist, Barts Health NHS Trust Institute of Health Informatics Research, University College London
Professor Heather M Wallace PhD FRCPath FRSC FRSB FBTS FBPhS ERT Professor Emeritus of Biochemical Pharmacology and Toxicology, University of Aberdeen
Professor David Moore MBChB MD MSc DTM&H Professor of Infectious Diseases and Tropical Medicine, London School of Hygiene and Tropical Medicine and Consultant in Infectious Diseases and Tropical Medicine, Hospital for Tropical Diseases, University College London Hospital
Mr David Crundwell Lay Representative
Summary minutes
Summary minutes are prepared on the basis that no personal, commercial or otherwise confidential information is disclosed.
See the final summary minutes for CHM and EAGs from 2014 onwards, which you can download.
Previous minutes can be seen on the MHRA pages on the National Archives.
CHM meeting dates
2023
| Jan | Feb | March | April | May | June | July | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 26/27 | 23/24 | 23/24 | 27/28 | 25/26 | 29/30 | 27/28 | 24/25 | 28/29 | 26/27 | 23/24 | 21/22 |
2024
| Jan | Feb | March | April | May | June | July | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 25/26 | 22/23 | 21/22 | 25/26 | 30/31 | 27/28 | 25/26 | 29/30 | 26/27 | 24/25 | 21/22 | 19/20 |
2025
| Jan | Feb | March | April | May | June | July | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 23/24 | 27/28 | 27/28 | 24/25 | 29/30 | 26/27 | 24/25 | 28/29 | 25/26 | 30/31 | 27/28 | 18/19 |
Antidepressant Risk Minimisation Expert Working Group
Remit
To review the views of patients and patients’ families about the effectiveness of warnings on the risks of suicidal behaviours as presented in the current patient information leaflets and any significant new primary data published since 2019 (acknowledging the quality of evidence) on the risk of suicidal behaviours.
To review the views from patients about the effectiveness of warnings about the risk of sexual dysfunction where symptoms continue on stopping treatment for those products with existing warnings in the current patient information leaflets and any new primary data published since 2019 (acknowledging the quality of evidence) on the risk of sexual dysfunction where symptoms continue after treatment with an antidepressant is stopped
To consider whether additional measures are required to raise awareness of the advice and warnings about the risk of suicidal behaviours and sexual dysfunction where symptoms continue after stopping for those products with existing warnings
And to advise the Commission on Human Medicines on any recommendations for additional risk minimisation measures on the risk of suicidal behaviour associated with all antidepressants and sexual dysfunction which may continue on stopping treatment and to advise on the monitoring of the impact of any introduced additional regulatory action.
Chair
Professor Angela Thomas OBE MB BS PhD FRCPE FRCPath, University of Edinburgh
Members
Professor Angela Thomas OBE MB BS PhD FRCPE FRCPath University of Edinburgh
Professor Tony Avery GP and Professor of Primary Health Care, University of Nottingham; National Clinical Director for Prescribing, NHS England
Professor Arianna Di Florio MD PhD, Professor of Psychiatry, Cardiff University
Professor Nicol Ferrier, Emeritus Professor of Psychiatry, Newcastle University
Dr Jamie Fraser BSc (Hons) MBChB MRCGP GP Partner, Southside Surgery, Inverness
Ellie Gordon, Royal College of Nursing
Ms Susan Hunneyball BSc (Hons) Member of the Pharmacovigilance Expert Advisory Group (PEAG) and Advisory Board on the Registration of Homeopathic Products (ABRHP)
Professor David Kessler MD MRCGP MRCPSYCH MBBS BA Professor of Primary Care, Bristol Medical School, University of Bristol
Professor Glyn Lewis, Professor of Psychiatric Epidemiology, University College London
Dr Ali Mears, Consultant in Sexual Health, Imperial College Healthcare NHS trust
Dr Barry Miller MB ChB FRCA FFPMRCA Consultant, Pain Management and Anaesthetics, Bolton NHS Foundation Trust
Professor David G C Owens MD (Hons) FRCP FRCPsych Professor Emeritus of Clinical Psychiatry, Edinburgh University
Carol Paton, Joint-Head, Prescribing Observatory for Mental Health, Royal College of Psychiatrists
Ms Linda Pepper BA MA (Education) Member of the Medicines for Women’s Health Expert Advisory Group (MWHEAG) and the Isotretinoin Expert Working Group (IEWG)
Mr Peter Pratt National Specialist Advisor, Mental Health Pharmacy, NHS England
Professor Vanessa Raymont MBChB MSc MRCPsych, Associate Professor, University of Oxford and Honorary Consultant Psychiatrist, Oxford Health NHS Foundation Trust
Dr Aditya Sharma, Clinical Senior Lecturer and Hon Consultant in child and adolescent psychiatry, Newcastle University and Clinical Lead for National Specialist Adolescent Mood disorders Service, CNTW NHS Foundation Trust
Professor David Taylor PhD FRPharmS FRCPE FRCPsych(Hon) Director of Pharmacy and Pathology
Dr Hoo Kee Tsang BSc(Hons) MB BCh FRCA FFPMRCA, Consultant in Pain Medicine and Anaesthesia, Clinical Director of Pain Services, Liverpool University Hospitals NHS Foundation Trust, member of the Royal College of Anaesthetists and the Faculty of Pain Medicine training and assessment committees
Dr Morris Zwi MBBCh FRCPsych Honorary Consultant Child & Adolescent Psychiatrist, South West London & St George’s NHS Mental Health Trust
Cardiovascular, Diabetes, Renal, Respiratory and Allergy EAG
Remit
To advise CHM on the safety and efficacy of medicines for used for the treatment and prevention of cardiovascular, diabetes, renal, respiratory and allergy diseases.
Chair
Professor Amanda Adler MD PhD FRCP Professor of Diabetic Medicine and Health Policy, University of Oxford
Members
Dr Hassan Kahal PhD, FRCP, PG CertMedEd, SCOPE, Consultant in Diabetes, Endocrinology, and Obesity Medicine, Southmead Hospital, North Bristol NHS Trust, Bristol
Professor John Petrie BSc(Hons) MBChB PhD FRCP(Glasg) FRCP(Edin) Professor of Diabetes & Director of Glasgow Clinical Trials Unit, University of Glasgow
Dr Rona Smith MA(Cantab) MB BChir(Cambridge) MD(Cantab) MRCP(London) Associate Professor of Nephrology, University of Cambridge; Honorary Consultant in Nephrology and Vasculitis, Cambridge University NHS Foundation Trust.
Professor Sandosh Padmanabhan MBBS MD PhD FRCP(Glasg) FRCP(Edin) FBPhS FBIHS Professor of Cardiovascular Genomics and Therapeutics, University of Glasgow
Professor Theresa McDonagh BSc (Hons), MB ChB (Hons), MD (Distinction), FRCP, FESC, FHFA Consultant Cardiologist, King’s College Hospital, London & Professor of Heart Failure King’s College, London
Dr Patrick Holmes MB BS MSc MRCGP GP Partner, St. George’s Medical Practice, Darlington
Professor Anita K Simonds MD FRCP FERS Professor Emeritus of Respiratory and Sleep Medicine, National Heart and Lung Institute, Imperial College, London & Honorary Consultant Respiratory and Sleep Physician, Royal Brompton & Harefield Hospital, Sydney Street, London
Professor William G. Herrington MA(Cantab) MBBS(London) MD(Cantab) FRCP(London) Professor of Trials and Epidemiology of Kidney Disease. Medical Research Council-Population Health Research Unit at the University of Oxford; Honorary Consultant Nephrologist, Oxford Kidney Unit
Dr Wajid Hussain BSc (Hons) MB ChB (Hons) MSc FRCP Consultant Cardiologist, Royal Brompton and Harefield Hospitals, Part of Guys and St Thomas’ NHS Foundation Trust
Dr Amine Boualem MD MRCGP PGDip(Diabetes) AHEA GP Partner, East Barnwell Health Centre, Cambridge
Professor Michael Steiner MB BS BSc MD FRCP Professor in Respiratory Medicine and Honorary Consultant, Dept of Respiratory Science, University of Leicester
Professor Mark Evans BSc MB BS MD FRCP Professor of Diabetic Medicine, University of Cambridge and Consultant Physician, Cambridge University Hospitals
Dr Shuaib Nasser MA MBBS MD FRCP Consultant Allergist and Respiratory Physician, Head of Allergy Cambridge University Hospital NHS Foundation Trust, Cambridge
Meeting dates
2024
| Jan | Mar | April | June | Sept | Nov |
|---|---|---|---|---|---|
| 15 | 12 | 17 | 19 | 20 | 11 |
2025
| Jan | Mar | May | July | Sept | Nov |
|---|---|---|---|---|---|
| 16 | 13 | 15 | 16 | 15 | 21 |
Chemistry, Pharmacy and Standards EAG
Remit
To advise the CHM on the quality in relation to safety and efficacy of medicinal products which are the subject of marketing authorisation applications and to advise on such other matters as are referred to it.
Chair
Professor Yvonne Perrie BSc Hons MRPharmS FAPS FSB PhD Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde.
Members
Professor Hannah Batchelor BSc PhD Professor of Pharmaceutics and Biopharmaceutics, Strathclyde Institute of Pharmaceutical and Biomedical Sciences, University of Strathclyde
Professor Barbara R Conway BSc (Pharm) PhD FRPharmS CMgr FCMI Head of Pharmacy and Professor of Pharmaceutics, University of Huddersfield, Huddersfield
Dr Majella Lane BSc PhD – (Vice Chair) Senior Lecturer in Pharmaceutics, UCL School of Pharmacy
Professor Afzal R Mohammed BPharm PhD Professor of Pharmaceutics, Aston Pharmacy School, Aston University
Mrs Ruth Paulin BPharm MRPharmS Practising Community Pharmacist.
Professor Darragh Murnane PhD BSc (Pharm) PhD MRPharmS Professor of Pharmaceutics and Associate Dean (Enterprise), University of Hertfordshire
Professor Susannah E Walsh PhD BSc MBA Head of School, Professor of Pharmaceutical Microbiology, Pharmacy and Life Sciences, Robert Gordon University
Professor Ben Forbes BPharm PhD Professor of Pharmaceutics, Institute of Pharmaceutical Science, Kings College London
Mr Hadar Zaman MPharm, MFRPSII, IPresc, FHEA Associate Professor in Pharmacy Practice and Head of School for Pharmacy and Medical Sciences, University of Bradford, , Associated Non-Executive Director Barnsley Hospital
Mr Robert Lowe BPharm FRPharmS Practising Hospital Pharmacist, Specialist Pharmacy Services - East of England
Professor Luigi (Gino) Martini BSc (Hons), PhD, MBA, FRPharmS, FRSC Chief Executive Precision Health Technology Accelerator (PHTA), University of Birmingham Honorary Professor in Pharmacy, University of Birmingham
Dr Federico Brucoli Pharm. D. PhD CChem MRSC mGPhC FHEA Senior Lecturer in Medicinal Chemistry, Leicester School of Pharmacy, De Montfort University, Leicester
Professor Nikoletta Fotaki Pharmacy Degree (Ptychion) MSc PhD Professor of Biopharmaceutics, Centre for Therapeutic Innovation and Department of Life Sciences, University of Bath
Meeting dates
2024
| Oct | Nov | Dec |
|---|---|---|
| 22 | 19 | 17 |
2025
| Jan | Feb | March | Apr | May | June | Jul | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|
| - | 25 | 25 | 22 | 27 | 24 | tbc | tbc | tbc | tbc | tbc | tbc |
Clinical Trials, Biologicals and Vaccines EAG
Remit
To advise the CHM on:
- first time in human (FTIM) studies with new compounds acting (directly or indirectly) via the immune system with a novel target or a novel mechanism of action or having a secondary potential effect on the immune system via a mechanism of action which currently is not well characterised
- FTIM studies with novel compounds acting via a possible or likely species specific mechanism
- any FTIM studies which are otherwise seen as requiring expert advice
- other clinical trials involving classes of compound where MHRA may wish to seek external expert advice or CHM may wish to have oversight
- whether a product’s mechanism of action is novel and comes within the scope of the EAG
- pre-meeting scientific advice documentation for within scope compounds
- other clinical trials where MHRA may wish to seek advice or where there is a difficult risk benefit balance
- other clinical trials involving products where a new class safety issue has been identified
- the quality, safety and efficacy of medicinal products of biological or biotechnological origin including vaccines which are the subject of marketing authorisation applications; and to advise on such other matters as are referred to it
Chair
Professor Marc Turner MB ChB PhD MBA FRCP FRCPath FRSE Professor of Cellular Therapy; Director Scottish National Blood Transfusion Service (SNBTS)
Members
Professor Farzin Farzaneh DPhil FRCPath FRSB, Professor of Molecular Medicine, King’s College London, Honorary Consultant in Specialist Medicine, King’s College Hospital NHS Trust
Professor Chris Goldring BSc PhD PGCert FBPhS, Professor of Pharmacology, Department of Pharmacology and Therapeutics, The University of Liverpool.
Dr Robin Thorpe PhD FRCPath Retired, Head, Division of Biotherapeutics, National Institute for Biological Standards and Control (NIBSC)
Dr Kirstie Shearman LLB MA PhD (Lay member) Policy Manager, Health Research Authority
Meeting dates
2025
| Jan | Feb | March | Apr | May | June | July | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 21 | 25 | 25 | 22 | 27 | 23 | 22 | 26 | 22 | 27 | 24 | 15 |
2024
| Jan | Feb | Mar | Apr | May | June | July | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 19 | 20 | 19 | 23 | 28 | 25 | 23 | 27 | 24 | 22 | 19 | 17 |
Gastroenterology, Rheumatology, Immunology and Dermatology EAG
Remit
To advise the CHM on the safety and efficacy of medicines for use in gastroenterological, rheumatological, immunological, and dermatological diseases.
Chair
Professor Anthony Williams BSc MSc MRCP, FRCPath, PhD Professor of Translational Medicine and Honorary Consultant in Clinical Immunology and Allergy, University of Southampton and University Hospital Southampton NHS Trust
Members
Professor Anjan Dhar DM, MD (Medicine), FRCPE, AGAF, Cert. Med. Ed, FHEA Professor of Medicine (Teesside University), Consultant Gastroenterologist, Clinical Lead for UGI Cancers, County Durham & Darlington NHS Foundation Trust
Dr Shahida Din BMSc, MBChB, PhD, FRCP (Edin) Consultant Gastroenterologist & NHS Research Scotland Clinician, NHS Lothian; Honorary Senior Clinical Lecturer, University of Edinburgh.
Professor Michael Ardern-Jones BSc MBBS DPhil FRCP Associate Professor, University of Southampton and Consultant Dermatologist
Professor Celia Moss OBE BA(Hons) MB BS MA MRCP DM FRCP MRCPCH Honorary Consultant Dermatologist, Birmingham Women’s and Children’s NHS FT, Honorary Professor of Paediatric Dermatology, University of Birmingham
Mr James Pitayanukul BSc (Hons) MSc CA Lay Member
Professor Nidhi Sofat PhD MBBS FRCP PGCert FHEA Professor of Rheumatology, St Georges University London
Dr Ravishankar Sargur MD, FRCPath, FRCP, MBA Consultant Clinical Immunologist and Clinical Lead for Laboratory Immunology, Northern General Hospital, Sheffield
Professor Stuart Ralston MB ChB MD FRCP FMedSci FRSE FFPM (Hon) Professor of Rheumatology, University of Edinburgh, Western General Hospital, Edinburgh
Meeting dates
2024
| Jan | Feb | Mar | Apr | May | Jun | Jul | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|
| 16 | 14 | 15 | 17 | 17 | 14 | 17 | 3 | 16 | 12 | 13 |
Infection EAG
Remit
To advise the Commission on the safety and efficacy of medicines for use in infections including HIV, AIDS and viral hepatitis.
Chair
Professor David Dockrell MB BCh MD FRCPI FRCP (Glas) FACP Professor of Infection Medicine, University of Edinburgh
Members
Professor Brian Angus BSc MBChB MA (Oxon) DTM&H FRCP FFTM Reader in Infectious Diseases, University of Oxford
Dr Michael Brown BA BM BCh FRCP PhD DTM&H Consultant Physician, Infectious Diseases & Acute Medicine, & Clinical Director, Division of Infection, University College London Hospitals NHS Foundation Trust & Honorary Associate Professor, Clinical Research Sept, London School of Hygiene & Tropical Medicine
Professor Andrew Freedman M.A, M.B, B. Chir, M.D, FRCP (Lond.), FRCP (Edin.) Consultant in Infectious Diseases / Vaccine Trials, Cardiff & Vale UHB, Honorary Professor, Cardiff University School of Medicine
Professor Richard J C Gilson MD FRCP Professor of Sexual Health & HIV Medicine, Director of the UCL Centre for Clinical Research in Infection Sexual Health & Deputy Director of the UCL Institute for Global Health
Dr Richard Hobson MB BS MRCP (UK) FRCPath PhD LLM Consultant Microbiologist and Honorary Senior Lecturer, Harrogate & District NHS Foundation Trust/University of Leeds
Dr Lim S Jones MBBCh, PhD, FRCPath Consultant Microbiologist, Public Health Wales Microbiology, Cardiff; Clinical Lead Specialist Antimicrobial Chemotherapy Unit, Cardiff; Chair of the All Wales Medical Microbiology Development & Standardisation Group
Dr Matthias Schmid MD FRCP DTMH Consultant Physician, Head of Department of Infection & Tropical Medicine, Director of Elective Studies Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne
Professor Geraint Rhys Davies BM DTM&H PhD FRCP Professor of Infection Pharmacology, University of Liverpool, Honorary Consultant in Infectious Diseases, Liverpool University Hospitals Foundation Trust
Dr Louis Grandjean MBBS BSc MSc PhD MRCPCH Associate Professor Paediatric Infectious Diseases Great Ormond Street Hospital and University College London
Mrs Stella O’Brien MA (Hons) Lay Member
Medicines for Women’s Health EAG
Remit
To advise the CHM on the safety and efficacy of medicines related to endocrinology and women’s reproductive health from menarche to menopause and conditions related to the menopause, such as osteoporosis. The medicines covered will include medicines for contraception, emergency contraception and termination of pregnancy; medicines for infertility and assisted conception; hormone replacement therapy (HRT) and non-hormonal treatments for osteoporosis.
Chair
Professor Philip Hannaford MBChB, MD, FRCGP, FFPH, FFSRH, FRSE Emeritus Professor of Primary Care, University of Aberdeen
Members
Dr Caitlin Dean RGN, MSc, PhD (Lay member) Chair Trustee, Pregnancy Sickness Support
Dr Kenneth Hodson MD MBChB MRCP(UK) MRCOG Head of UK Teratology Information Service UK Teratology Information Service
Dr Asha Kasliwal FRCOG FFRSH FRCGP (Hon) FFPH (Hon)
Consultant in Community Gynaecology and Reproductive Health, Manchester University NHS Foundation Trust Hathersage Centre
Dr Jonathan Lord MD FRCOG FHEA
Consultant Obstetrician and Gynaecologist, Royal Cornwall Hospitals NHS Trust
Dr Louise Massey MBChB FFSRH FFPH
Consultant in Sexual and Reproductive Health Aneurin Bevan University Health Board
Ms Linda Pepper BA MA (Education) - (Lay member) Independent Consultant: patient and public involvement in healthcare
Dr Julia Prague MBBS PhD MRCP(UK) BSc Consultant in Endocrinology, Diabetes, and General Internal Medicine, Royal Devon and Exeter NHS Foundation Trust, and Honorary Senior Clinical Lecturer, College of Medicine and Health, University of Exeter
Professor Stuart Ralston MB ChB MD FRCP FMedSci FRSE FFPM (Hon) Professor of Rheumatology, University of Edinburgh, Western General Hospital, Edinburgh
Professor Laurie Tomlinson MBBS MSc PhD NIHR research Professor, Faculty of Epidemiology and Population Health London School of Hygiene & Tropical Medicine
Dr Diana Wellesley FRCP (Vice Chair) Honorary Consultant and Honorary Senior Lecturer in Clinical Genetics, Wessex Clinical Genetics Service, Princess Anne Hospital Southampton
Professor Laura A. Magee MD (Hons)
Cert (ClinPharm), FRCPC, MSc, FACP, FRCOG
Professor of Women’s Health, King’s College London
Meeting dates
2024
| Feb | Jun | Jul | Sep | Oct | Dec |
|---|---|---|---|---|---|
| 27 | 19 | 15 | 5 | 9 | 11 |
2025
| Feb |
|---|
| 5 |
Neurology, Pain and Psychiatry EAG
Remit
To advise the CHM on the safety and efficacy of medicines for use in neurological conditions, pain management and psychiatric conditions.
Chair
Professor David Hunt MB BChir FRCP PhD Consultant Neurologist, NHS Lothian, Professor of Neuroinflammatory Medicine, University of Edinburgh
Members
Dr Lisa Brownell BSc(Hons) MBChB PGCertMedEd FHEA FRCPsych Associate Medical Director, Birmingham and Solihull Mental Health NHS Foundation Trust Chair of Area Prescribing Committee, Birmingham, Sandwell, Solihull and Environs
Dr Barry Mark Miller MB ChB FRCA FFPMRCA Consultant in Pain Medicine and Anaesthesia, Bolton NHS Foundation Trust. Board Member of the Faculty of Pain Medicine.
Professor David G C Owens MD (Hons) FRCP FRCPsych Professor of Clinical Psychiatry, Edinburgh University
Dr Waqar Rashid MBBS BSc MRCP(UK) PhD Consultant and Honorary Clinical Senior Lecturer in Neurology, Brighton and Sussex University Hospitals NHS Trust, member of the Multiple Sclerosis Society
Dr Fergus Rugg-Gunn MB BS MRCP PhD Consultant Neurologist, National Hospital for Neurology and Neurosurgery, Queen Square, London
Dr Aditya Sharma MBBS MD MRCPsych PhD Clinical Senior Lecturer and Honorary Consultant in Child and Adolescent Psychiatry at Newcastle University and Cumbria, Northumberland Tyne and Wear NHS Foundation Trust
Dr Hoo Kee Tsang BSc(Hons) MB BCh FRCA FFPMRCA Consultant in Pain Medicine and Anaesthesia, Clinical Director of Pain Services, Liverpool University Hospitals NHS Foundation Trust, member of the Royal College of Anaesthetists and the Faculty of Pain Medicine training and assessment committees.
Meeting dates 2025
| January | March | June | September | December |
|---|---|---|---|---|
| 15 | 5 | 11 | 17 | 3 |
Meeting dates 2024
| January | March | June | September | October | December |
|---|---|---|---|---|---|
| 10 | 6 | 12 | 18 | 17 | 4 |
Oncology and Haematology EAG
Remit
To advise the CHM on the safety, quality and efficacy of medicines used in the treatment of malignant disease or blood disorders.
Chair
Professor Poulam Patel PhD, MBBS, FRCP Professor of Clinical Oncology, University of Nottingham
Members
Professor Janet E Brown FRCP, MD,MSc, BMedSci, MBBS Academic Unit of Clinical Oncology, Department of Oncology and Metabolism, Weston Park Hospital, University of Sheffield.
Dr Rebecca Kristeleit BSc MBChB PhD FRCP FRSB Consultant Medical Oncologist, Guy’s and St Thomas’ NHS Foundation Trust.
Dr Perminder Tony Singh Dhillon Bsc, MB BS, FRCP, PhD
Consultant Medical Oncologist, Royal Surrey Hospital, Guildford, Surrey and Hon. Senior Lecturer in Oncology, University of Surrey
Professor Siow Ming Lee PhD FRCP Professor of Medical Oncology, Consultant Medical Oncologist
Dr Debashis Sarker MBChB PhD FRCP Reader in Experimental Oncology, King’s College London Consultant Medical Oncologist, Guy’s, St Thomas’ and King’s College Hospitals
Professor James Spicer FRCP, PhD Professor of Experimental Cancer Medicine, King’s College London; Consultant in Medical Oncology, Guy’s & St Thomas’ NHS Foundation trust Vice Chair
Dr Ben Uttenthal MA MB BS PhD MRCP FRCPath Consultant Haematologist, Cambridge University Hospitals
Dr Anjum Khan PhD MBChB FRCPath MRCP
Consultant Haematologist, Leeds Teaching Hospitals NHS Trust.
Meeting dates 2023
| July | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|
| 25 | 17 | 21 | 19 | 16 | 14 |
Meeting dates 2024
| Jan | Feb | March | Apr | May | June | July | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 11th | 15th | 14th | 18th | 23rd | 20th | 18th | 22nd | 19th | 17th | 14th | 12th |
Paediatric Medicines EAG
The remit of the EAG is to advise the CHM on the safety, quality and efficacy of medicines for paediatric use, including all matters relating to the implementation of the EU Paediatric Regulation.
Chair
Professor Steven Cunningham MBChB PhD FRCPCH Professor of Paediatric Respiratory Medicine, University of Edinburgh and Honorary Consultant, Royal Hospital for Children and Young People, NHS Lothian, Edinburgh
Members
Mrs Catrin Barker, Chief Pharmacist, Pharmacy Department, Alder Hey Children’s NHS FT, Eaton Road, Liverpool
Dr Simon B Drysdale BSc (Hons), MBBS, FRCPCH, PhD, PgDip PID (Oxford), FHEA Senior Lecturer, Oxford Vaccine Group, University of Oxford, Consultant in Paediatric Infectious Diseases and Immunology, Children’s Hospital, Oxford
Dr Daniel Hawcutt BSc (Hons), MB ChB (Hons), MD, MRCPCH, Senior Lecturer Paediatric Clinical Pharmacology, Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool
Dr Kathryn Johnson MBChB FRCPCH, Consultant Neonatologist, Leeds Teaching Hospitals NHS Trust and Honorary Senior Lecturer, Leeds University Vice Chair
Dr Caroline Jones MB ChB FRCPCH MD, Consultant Paediatric Nephrologist, Alder Hey Children’s NHS Foundation Trust
Dr Daniel E Lumsden MB/BChir MA Cantab MSc PhD FRCPCH, Consultant Paediatric Neurologist, Evelina London Children’s Hospital, Adjunct Clinical Senior Lecturer, Department of Perinatal Imaging, King’s College London
Dr Jacqueline McMurtrie BSc (Hons), MSc, PhD Lay Representative
Dr Clare Pain BMBS, MSc, MRPCH, Consultant Paediatric Rheumatologist, Clinical Lead for Rheumatology Honorary Clinical Lecturer, University of Liverpool Co-Chair of NIHR CRN: children/Versus Arthritis Paediatric Rheumatology Clinical Studies Group Associate Director, UK Experimental Arthritis Treatment Centre for Children (Behcet’s and scleroderma workstreams)
Dr Guido Pieles PhD MD, Consultant Congenital Cardiologist, Congenital Hear Unit, Bristol Heart Institute
Professor Shirley Price MSc, PhD, FBTS, FRSB, ERT, FHEA,FRSC, MBPharmacolSoc, Emerita Professor of Toxicology, University of Surrey Visiting Professor of Toxicology, University of Hertfordshire
Mrs Julia Taylor MSc BSc, Paediatric Advanced Nurse Practitioner, High Dependency Unit, Alder Hey Children’s NHS Foundation Trust
Mrs Rhian Thomas-Turner LLM, PG Dip Legal Practice
Lay Representative. Research and Development Lead, Noah’s Ark Children’s
Hospital for Wales, Cardiff and Vale University Health Board
Dr William John Watkins BSc PhD, Senior Statistician/Lecturer, College of Biomedical & Life Sciences, Cardiff University
Dr Martin William English BMSc, MBChB, MD, FRCP(Glas), FRCPCH, Consultant Paediatric Oncologist, Birmingham Women’s and Children’s Hospital NHS Foundation Trust
M Dr Ashley Liew MBChB, MRCPsych, MSc. Consultant Paediatric Neuropsychiatrist, Evelina London Children’s Hospital and South London & Maudsley NHS Foundation Trust. Honorary Senior Research Fellow, University of Warwick.
Meeting dates
2024
| Jan | Feb | March | Apr | May | June | July | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 10 | 13 | 13 | 10 | 15 | 18 | 10 | 21 | 17 | 9 | 6 | 3 |
Meeting dates
2025
| Jan | Feb | March | Apr | May | June | July | Aug | Sept | Oct | Nov | Dec |
| 15 | 18 | 18 | 15 | 21 | 18 | 16 | 20 | 16 | 22 | 19 | 20 |
Pharmacovigilance EAG
PEAG now review applications for access to Type II Yellow Card data, the completed application form should be emailed directly to vigilanceservice@mhra.gov.uk.
Remit
To advise the CHM on the following in relation to human medicines including herbal products:
- the public health importance of potential new signals
- the confirmation and quantification of risks identified
- appropriate risk minimisation measures including communications
- design and progress of pharmacovigilance plans
- methodologies for pharmacovigilance.
Chair
Professor Jamie Coleman MD MA (Med Ed) FRCP FBPhS Professor in Medical Education/Consultant Clinical Pharmacologist, University of Birmingham
Members
Dr Anna Schultze BSc MSc PhD
Assistant Professor in Pharmacoepidemiology, Faculty of Epidemiology and Public Health, London School of Hygiene and Tropical Medicine
Professor Darren Ashcroft BPharm MSc PhD FRPharmS Professor of Pharmacoepidemiology, Division of Pharmacy and Optometry, Manchester University
Professor Ann Daly BA PhD FBPhS Professor of Pharmacogenetics, Faculty of Medical Sciences, Newcastle University
Dr Dan Hawcutt BSc MB ChB MD MRCPCH Senior Lecturer in Paediatric Clinical Pharmacology, Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool.
Dr Malcolm Oswald, Lay Member
Honorary Research Fellow in Law, University of Manchester
Professor Rupert Payne MB ChB PhD MRCGP FRCPE FBPhS FHEA Professor of Primary Care & Clinical Pharmacology, University of Exeter
Ms Susan Hunneyball BSc (Hons) Lay Member
Mrs Alana Adams BPharm (Hons), MSc, IP, MRPharmS
Principal Pharmacist Medicines Information, advice and Safety, University of Cardiff
Dr Richard FitzGerald MD MBChB PhD FRC
CRF Director, NIHR Royal Liverpool and Broadgreen CRF
Professor Patricia McGettigan MD, BSc, MB, BCh, BAO, BA
Professor in Clinical Pharmacology and Medical Education and Consultant Physician, Barts Health Trust
Professor Reecha Sofat MBBS, FRCP, PhD Breckenridge Chair of Clinical Pharmacology and Therapeutics, University of Liverpool
Dr Fraz Arif Mir MA FRCP Consultant Physician, Cambridge University Hospitals NHS Foundation Trust
Dr Nashat Qamar MB ChB MRCGP MSc DRCOG BSc (hons)
PCN Clinical Director and GP Partner, Hall Green Health, Birmingham
Meeting dates
2025
| Jan | Feb | March | Apr | May | June | July | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 15 | 19 | 19 | 16 | 22 | 18 | 16 | 21 | 17 | 22 | 19 | 11 |
2024
| Jan | Feb | March | Apr | May | June | July | Aug | Sept | Oct | Nov | Dec |
| 17 | 15 | 14 | 17 | 23 | 20 | 17 | 22 | 19 | 17 | 14 | 12 |
Type II Yellow Card data
PEAG now review applications for access to Type II Yellow Card data. The completed Type II Yellow Card data application form should be emailed directly to vigilanceservice@mhra.gov.uk.
Isotretinoin Expert Working Group
Terms of reference
The terms of reference for the IEWG are:
- to evaluate information from all available sources, including relevant stakeholders (patients, patient representatives, healthcare professionals, healthcare organisations, researchers, charity and patient organisations) on psychiatric effects suspected to be associated with isotretinoin. To consider whether regulatory action is required to minimise risk and ensure awareness of the risks
- to evaluate information from all available sources, including relevant stakeholders (patients, patient representatives, healthcare professionals, healthcare organisations, researchers, charity and patient organisations) on sexual disorders suspected to be associated with isotretinoin. To consider whether regulatory action is required to minimise risk and ensure awareness of the risks.
- to consider the impact of the available information on psychiatric effects and sexual disorders on the balance of benefits and risks of isotretinoin.
- to consider what research could be undertaken to further elucidate any risks and long-term impact of psychiatric effects and sexual disorders and inform risk minimisation measures.
- to make recommendations to the Commission on Human Medicines to improve the balance of benefits and risks for isotretinoin, to raise awareness of the associated risks and for further research to evaluate the risks.
Chair
Professor Angela Thomas OBE MB BS PhD FRCPE FRC Path
University of Edinburgh
Members
Professor Darren Ashcroft BPharm, MSc, PhD, FRPharmS Professor of Pharmacoepidemiology, Head, Drug Usage and Pharmacy Practice Group, University of Manchester
Professor Amanda Drake FRCPE Personal Chair of Epigenetics and Metabolism, Academic Director, Academic Foundation Programme, Associate Director, Edinburgh Clinical Academic Training Programme
Professor Nicol Ferrier BSc MB ChB MD FRCP FRCPsych Professor of Psychiatry and Honorary Consultant Psychiatrist, University of Newcastle
Dr Arianna Di Florio Clinical Senior Lecturer, Cardiff University Honorary Consultant Psychiatrist, Cardiff and Vale University Health Board, Adjunct Assistant Professor, University of North Carolina at Chapel Hill
Dr Clive Grattan BA MA MB BChir FRCP MD ILT Consultant Dermatologist, St John’s Institute of Dermatology, Guy’s Hospital, London
Professor David Gunnell MB ChB MRCGP PhD MSc FFPHM Professor of Epidemiology, University of Bristol
Professor Peter C Hindmarsh Professor of Paediatric Endocrinology, University College London
Dr Karen Miller BSc MBBS DRCOG DCH DFFP FRCGP
GP Partner, Adelaide Medical Centre, London
Professor Rod Mitchell Professor of Developmental Endocrinology, Honorary Consultant Paediatric Endocrinologist, UKRI Future Leaders Fellow/Academic Lead for Public Engagement MRC Centre for Reproductive Health, Queens Medical Research Institute, Edinburgh
Professor Gudrun Moore Professor of Clinical and Molecular Genetics, Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health
Mr Giangiacomo Ollandini FRCS MD Milton Keynes Hospital NHS Foundation Trust - Urology Urologist, Andrologist, MSc in andrological surgery and gender disorder
Ms Linda Pepper BA MA (Education) Independent Consultant: patient and public involvement in healthcare
Dr Amr Abdel Raheem MB BCh, MSc, DipSurg, PhD, FECSM, FEAA University College London Hospitals NHS Foundation Trust infertility & contraception, Peyronies Disease, Erectile Dysfunction and male Hypogonadism
Mrs Madeleine Wang BA (Hons) Lay Representative, Patient Advocate
Professor Allan Young Vice Dean, Academic Psychiatry (Interim), Director, Centre for Affective Disorders NIHR Senior Investigator, Academic Director, Psychological Medicine and Older Adults Clinical Academic Group, Immediate Past President of International Society for Affective Disorders, President British Association for Psychopharmacology, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London
Observers
National Institute for Health and Care Excellence (NICE)
NHS Improvement
The Care Quality Commission
Primary Care Dermatology Society (PCDS)
COVID-19 Therapeutics Expert Working Group
Remit
- To advise on the safety and efficacy of candidate anti-viral agents, immune-based therapies and repurposed agents for the treatment and prevention of COVID-19 infection, based on available scientific data.
- To review the robustness of the evidence of supporting agents used for the treatment of COVID-19 complications, including agents based on putative mechanisms, as currently available and based on emerging data.
- To advise on strategies and study designs to collect efficacy and safety data including novel trial designs.
- To advise on measures to minimise risks and optimise the benefit-risk balance of anti-viral agents, supportive therapies (e.g., corticosteroids, NSAIDS, chloroquine, immune modulators, etc) proposed for the treatment of COVID-19 infection and its complications.
- To advise on the benefits and risk of concomitant medications (e.g., ACE inhibitors/ AT-II blockers or immunosuppressants).
- To advise on measures to monitor safety and effectiveness of risk minimisation measures relating to these medicinal products.
- To advise the Commission on Human Medicines.
Chair
Professor Jonathan S Friedland MA PhD FRCP FRCPE FRCPI FESCMID FMedSci Deputy Principal, St. George’s, University of London
Members
Professor Kenneth Baillie BSc(Hons) MBChB PhD FRCA FRCP FFICM
Professor of Experimental Medicine
Roslin Institute, University of Edinburgh
Ms Susan Bradford Lay Representative
Professor David Dockrell MB BCh MD FRCPI FRCP (Glas) FACP Professor of Infection Medicine, University of Edinburgh
Professor Richard J C Gilson MD FRCP Professor of Sexual Health & HIV Medicine, Director of the UCL Centre for Clinical Research in Infection & Sexual Health & Deputy Director of the UCL Institute for Global Health
Sir Michael Jacobs Consultant & Hon. Senior Lecturer in Infectious Diseases Royal Free London NHS Foundation Trust
Professor Nigel Klein BSc MBBS MRCP PhD FRCPCH Consultant, Great Ormond Street Hospital for Children NHS Trust; Professor of Infectious Diseases and Microbiology, Institute of Child Health, UCL
Dr Siraj Misbah MBBS (Hons) MSc FRCP FRCPath - Consultant Clinical Immunologist, Lead for Clinical Immunology, Oxford University Hospitals
Professor B Kevin Park BSc PhD FMedSci HonFRCP FBTS HonFBPhs Professor of Pharmacology, University of Liverpool
Professor Deenan Pillay Professor of Virology, UCL Pro-Vice-Provost International
Professor Sir Munir Pirmohamed MB ChB (Hons) PhD FRCP FRCP (Edin) FBPhS, FFPM (Hon) FMedSci David Weatherall Chair of Medicine, University of Liverpool, NHS Chair of Pharmacogenetics, Director of the Wolfson Centre for Personalised Medicine, Director of the Centre for Drug Safety Science
Professor Shirley Price MSc, PhD, FBTS, FRSB, ERT, FHEA ,FRSC, MBPharmacolSoc Emerita Professor of Toxicology, University of Surrey Visiting Profesor of Toxicology, University of Hertfordshire
Observers
Professor Stuart Ralston MB ChB MD FRCP FMedSci FRSE FFPM (Hon) Professor of Rheumatology, University of Edinburgh, Western General Hospital, Edinburgh
Department of Health & Social Care
Public Health England
NHS England & NHS Improvement
National Institute for Health and Care Excellence (NICE)
COVID-19 Vaccines Safety Surveillance Methodologies Expert Working Group
Remit
Pre-deployment phase
- To landscape the different healthcare datasets that are currently available in the UK to capture near real-time information on COVID-19 vaccine exposure and study endpoints relevant to vaccine safety and potential for disease enhancement (and effectiveness). This should take into account a range of potential scenarios for vaccine deployment (i.e. the point of administration and any prioritised/targeted immunisation), and should advise on the need for further data capture and linkage.
- To advise on the most suitable study endpoints and design(s) to monitor COVID-19 vaccine safety, and potential for disease enhancement (and effectiveness).
- To support engagement with UK institutions who may be planning/in a position to conduct COVID-19 vaccine safety studies. This is to encourage and facilitate studies that are complementary in terms of objective and design, to avoid duplication and to accommodate a suitable range of study endpoints and scenarios for vaccine deployment.
- To advise on proposals for enhanced passive surveillance.
- To advise on communications in support of the pharmacovigilance strategy.
Post-deployment phase
- To advise on the emerging evidence from all data sources on the risks and benefits of vaccine(s) during the course of any COVID-19 immunisation campaign in the UK. This includes measures to minimise risks, and optimise the benefit-risk balance for individual vaccines, such as any new precautions or restrictions on use.
- To advise on any communications to health professionals and the public.
- To advise on measures to monitor impact/effectiveness of any additional risk minimisation.
Chair
Dr Siraj Misbah MBBS (Hons) MSc FRCP FRCPath Consultant Clinical Immunologist, Lead for Clinical Immunology, Oxford University Hospitals & Chair of the Clinical Trials, Biologicals & Vaccines Expert Advisory Group (CTBVEAG) & Member of the Commission on Human Medicines (CHM)
Members
Professor Ian J Douglas BSc MSc PhD Senior Lecturer in Pharmacoepidemiology, London School of Hygiene & Tropical Medicine & Member of the Pharmacovigilance Expert Advisory Group (PEAG)
Professor Jonathan S Friedland MA PhD FRCP FRCPE FRCPI FESCMID FMedSci Deputy Principal, St. George’s, University of London & Chair of the Infections Expert Advisory Group (IEAG) & Member of the Commission on Human Medicines (CHM)
Sir Michael Jacobs MA PhD MB BS FRCP FRCP Edin DTM&H Clinical Director of Infection, Royal Free London NHS Foundation Trust & Hon. Senior Lecturer, Liverpool School of Tropical Medicine
Professor Simon De Lusignan Professor of Primary Care and Clinical Informatics, University of Oxford
Professor Rupert Payne MB ChB PhD MRCGP FRCPE FBPhS FHEA Professor of Primary Care & Clinical Pharmacology, University of Exeter. Member of the Pharmacovigilance Expert Advisory Group (PEAG)
Professor Sir Munir Pirmohamed MB ChB (Hons) PhD FRCP FRCP (Edin) FBPhS, FFPM (Hon) FMedSci David Weatherall Chair of Medicine, University of Liverpool, NHS Chair of Pharmacogenetics, Director of the Wolfson Centre for Personalised Medicine, Director of the Centre for Drug Safety Science
Professor Siobhan Quenby MBBS BSc MD FRCOG Professor of Obstetrics, Warwick University & Member of the Medicines for Women’s Health Expert Advisory Group (MWHEAG)
Professor Chris Robertson PhD MSc BSc Professor of Public Health Epidemiology, University of Strathclyde
Professor Calum Semple PhD FRCPCH FRCPE FHEA Professor of Outbreak Medicine University of Liverpool
Invited Experts
Professor Elizabeth Miller Department of Infectious Disease Epidemiology, Faculty of Epidemiology & Population Health, London School of Hygiene & Tropical Medicine
Professor Anthony Scott JCVI member, and Professor of vaccine epidemiology, Director HPRU in immunisation
Helen McDonald LSHTM Health Protection Research Unit
Jemma Walker LSHTM Health Protection Research Unit
Observers
Professor Liam Smeeth MBChB FRCGP FRCP MSc PhD FMedSci Professor of Clinical Epidemiology, London School of Hygiene & Tropical Medicine (LSHTM) & MHRA, Non-Executive Director (Board)
Visiting Experts
Professor Andrew Pollard FRCPCH PhD FMedSci Chief Investigator of the Oxford ChAD vaccine
Professor of Paediatric Infection and Immunity, Director of Graduate Studies, Department of Paediatrics, Vice Master, St Cross College, University of Oxford & Member of the Clinical Trials, Biologicals & Vaccines Expert Advisory Group (CTBVEAG)
Professor Robin Shattock Lead Scientist for the Imperial saRNA vaccine programme
Professor Sheena McCormack Clinical Project Lead at MRC CTU at UCL
COVID-19 Vaccines Benefit Risk Expert Working Group
Remit
- To advise CHM on the quality, safety and efficacy of COVID-19 vaccines and on the balance of benefit and risks prior to authorisation.
- To coordinate safety evaluation with the Clinical Trials, Biologicals and Vaccines Expert Advisory Group.
- To report its conclusions and recommendations to the Commission on Human Medicines.
- To advise on the emerging evidence from all data sources on the risks and benefits of vaccine(s) during the course of any COVID-19 immunisation campaign in the UK. This includes measures to minimise risks, and optimise the benefit-risk balance for individual vaccines, such as any new precautions or restrictions on use.
- To advise on any communications to health professionals and the public.
- To advise on measures to monitor impact/effectiveness of any additional risk minimisation.
Chair
Professor Sir Munir Pirmohamed MB ChB (Hons) PhD FRCP FRCP (Edin) FBPhS, FFPM (Hon) FMedSci, David Weatherall Chair of Medicine, University of Liverpool, NHS Chair of Pharmacogenetics, Director of the Wolfson Centre for Personalised Medicine, Director of the Centre for Drug Safety Science
Members
Professor Judith Breuer MD FRCPath FmedSci, Professor of Virology, University College London (UCL), Division of Infection and Immunity, London
Professor Gordon Dougan FRS, Department of Medicine, Cambridge Infectious Diseases, University of Cambridge
Mr V’Iain G Fenton-May BPharm MIPharm FRPharmS, Pharmaceutical Microbiologist
Professor Neil French MB ChB FRCP PhD, Head Department of Clinical Infection Microbiology and Immunology, Chair of Infectious Diseases & Global Health, Hon Consultant Infectious Diseases, Royal Liverpool & Broadgreen University Hospitals Trust
Professor David Goldblatt MB ChB FRCPCH FRCP PhD, Professor of Vaccinology and Immunology, Consultant in Paediatric Immunology, NIHR Senior Investigator, Great Ormond Street Hospital & University College London
Ms Susan Hunneyball BSc(Hons), Lay Member, Member of the Pharmacovigilance Expert Advisory Group (PEAG) and Advisory Board on the Registration of Homeopathic Products (ABRHP)
Professor Kimme Hyrich MD PhD FRCPC Professor of Epidemiology and Honorary, Consultant in Rheumatology, Centre for Musculoskeletal Research, Faculty of Biology Medicine and Health, University of Manchester and Kellgren Centre for Rheumatology, Manchester University NHS Foundation Trust
Sir Michael Jacobs MA PhD MB BS FRCP FRCP Edin DTM&H, Consultant in Infectious Diseases, Royal Free London NHS Foundation Trust; Hon. Senior Lecturer, University College London and Liverpool School of Tropical Medicine
Professor Helen J Lachmann MA MB BChir MD FRCP FRCPath, Professor of Medicine & Honorary Consultant Nephrologist, Clinical Director UCL Division of Medicine & Clinical Lead for National Amyloidosis Centre, University College London & Royal Free Hospital London NHS Foundation Trust & Vice-chair of the Clinical Trials, Biologicals & Vaccines Expert Advisory Group (CTBVEAG)
Professor Paul J Lehner PhD FRCP FMedSci FRS
Professor of Immunology and Medicine, Wellcome Trust Principal Research Fellow
Honorary Consultant Infectious Diseases, Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre Cambridge Biomedical Campus
Mr Robert Lowe BPharm FRPharmS, Practising Hospital Pharmacist, Specialist Pharmacy Services - East of England
Dr Siraj Misbah MBBS (Hons) MSc FRCP FRCPath, Consultant Clinical Immunologist, Lead for Clinical Immunology, Oxford University Hospitals & Member of the Commission on Human Medicines (CHM) & Chair of the Clinical Trials, Biologicals & Vaccines Expert Advisory Group (CTBVEAG)
Professor Yvonne Perrie BSc Hons MRPharmS FAPS FSB PhD, Chair in Drug Delivery, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow. Scotland
Professor Shirley Price MSc, PhD, FBTS, FRSB, ERT, FHEA, FRSC, MBPharmacolSoc, Emerita Professor of Toxicology, University of Surrey, Visiting Professor of Toxicology, University of Hertfordshire and Member of the Commission on Human Medicines (CHM)
Dr Andrew Riordan MD FRCPCH DTM&H, Consultant in Paediatric Infectious Diseases and Immunology, Honorary Clinical Lecturer, University of Liverpool, Alder Hey Children’s NHS Foundation Trust, Liverpool
Professor Chris Robertson PhD MSc BSc, Professor of Public Health Epidemiology, University of Strathclyde
Professor Kevin M G Taylor BPharm PhD FRPharmS, Chair of the British Pharmacopoeia Commission and Professor of Clinical Pharmaceutics, UCL School of Pharmacy, London
Dr Robin Thorpe BSc PhD FRCPath, Retired, Head, Division of Biotherapeutics, National Institute for Biological Standards and Control (NIBSC) & Member of the Clinical Trials, Biologicals & Vaccines Expert Advisory Group (CTBVEAG)
Professor Marc Turner MBBS PhD MBA FRCP FRCPath FHEA, Professor of Cellular Therapy; Medical Director Scottish National Blood Transfusion Service (SNBTS)
Professor Susannah Walsh BSc PhD MBA, Head of School, Professor of Pharmaceutical Microbiology, Pharmacy and Life Sciences, Robert Gordon University
Mrs Madeleine Wang BA (Hons), Lay Member & Member of the Clinical Trials, Biologicals & Vaccines Expert Advisory Group (CTBVEAG)
Professor Christopher Weir BSc MSc PhD FRSS, Cstat Professor of Medical Statistics & Clinical Trials, Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh & Member of Commission on Human Medicines (CHM)
Highly Personalised Medicines Expert Working Group (HPMEWG)
Remit
- To advise CHM on the quality, safety and efficacy of candidate highly personalised medicines.
- To advise CHM on the quality, non-clinical and clinical development of highly personalised medicines.
- To advise on the measures to characterise the clinical effectiveness of highly personalised medicines group in the clinical use setting.
- To advise on the measures to monitor short-term & long-term safety and minimise the risks of highly personalised medicines.
- To advise on healthcare practitioner and patient communications related to highly personalised medicines and regulatory nomenclature of cancer vaccines and immunotherapy.
Chair
Professor Sir Munir Pirmohamed MB ChB (Hons) PhD FRCP FRCP (Edin) FBPhS, FFPM (Hon) FMedSci, David Weatherall Chair of Medicine, University of Liverpool, NHS Chair of Pharmacogenetics, Director of the Wolfson Centre for Personalised Medicine, Director of the Centre for Drug Safety Science
Members
Professor Cameron Alexander CChem, FRSC, FHEA Professor of Polymer Therapeutics, Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham
Dr Robert Andrews Senior Lecturer FHEA, Cardiff University, Board Member of ELIXIR-UK
Dr Colin Brown PhD FRCPath Consultant Clinical Scientist -Head of H&I Laboratory Colindale, NHS Blood and Transplant
Professor Robert Brown BSc PhD Professor of Translational Oncology, Department of Surgery & Cancer, Imperial College London
Dr Peter Buckle FRSPH, FIEHF, FIEA, C.ErgHF Principal Research Fellow, NIHR London In Vitro Diagnostics Co-operative Department of Surgery and Cancer, Faculty of Medicine, Imperial College London
Professor Tom Clutton-Brock MBE MB ChB FRCP FRCA FFICM Director, Medical Devices Testing and Evaluation Centre, Clinical Director, NIHR HealthTech Research Centre in Devices, digital and robotics (HRC-DDR), Chair, NICE Interventional Procedures Advisory Committee, Chair, MHRA Interim Devices Working Group, Associate Medical Director, University Hospitals Birmingham NHS Foundation Trust, Professor of Anaesthesia & Intensive Care Medicine, University of Birmingham
Professor Jamie Coleman MD MA (Med Ed) FRCP FBPhS Professor in Medical Education/Consultant Clinical Pharmacologist, University of Birmingham
Mrs Julia Cons Lay Representative
Professor Ann Daly BA PhD FBPhS Professor of Pharmacogenetics, Faculty of Medical Sciences, Newcastle University
Professor Jon Deeks PhD CStat Professor of Biostatistics Public Health, Epidemiology and Biostatistics, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham
Dr Brendan Fish BSc PhD Director of Biologics & RNA Centre of Excellence, County Durham
Dr Vasantha Gowda MBBS FRCPCH MSc Paediatric Neurology Consultant & Paediatric Neuromuscular Service lead, Evelina London Children’s Hospital & Honorary Senior Lecturer, King’s College Hospital
Dr Alan Hodgkinson BSc (Hons), DPhil. Senior Lecturer, King’s College London
Dr Larissa Kerecuk FRCPCH Consultant Paediatric Nephrologist, Birmingham Women’s and Children’s NHS Foundation Trust
Professor Eric Lim MB ChB MD MSc FRCS(C-Th) Consultant Thoracic Surgeon, Royal Brompton Hospital, Professor of Thoracic Surgery, Imperial College London
Mr Robert Lowe BPharm FRPharmS Practising Hospital Pharmacist, Specialist Pharmacy Services - East of England
Professor Alan McIntyre PhD Director, Centre for Cancer Science, Biodiscovery Institute, School of Medicine, University of Nottingham
Dr Alisdair McNeill PhD FRCP (Edin) DCH FHEA
Senior Clinical Lecturer in Neurogenetics & Hon Consultant Clinical Geneticist and Associate Director of Student Affairs (Intercalation) & Editor-in-Chief European Journal of Human Genetics
Dr David Millrine PhD Translational Immunology Team lead, CRUK Cancer Biomarker Centre, University of Manchester
Professor Serena Nik-Zainal MA MBBChir MRCP PhD FMedSci NIHR Research Professor, Professor of Genomic Medicine & Bioinformatics, Early Cancer Institute, University of Cambridge, Department of Medical Genetics, Honorary Consultant in Clinical Genetics, Cambridge University Hospitals NHS Trust
Professor Christian Ottensmeier MD, PhD, FRCP. Professor of Molecular and Clinical Cancer Medicine, University of Liverpool
Professor Poulam Patel PhD, MBBS, FRCP Professor of Clinical Oncology, University of Nottingham
Professor Yvonne Perrie BSc PhD Chair in Drug Delivery, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow. Scotland
Professor Shirley Price MSc, PhD, FBTS, FRSB, ERT, FHEA, FRSC, MBPharmacolSoc Emerita Professor of Toxicology, University of Surrey, Visiting Professor of Toxicology, University of Hertfordshire
Professor Carlo Rinaldi MA MD PhD MSc Associate Professor in Neuroscience, University of Oxford
Professor Jacqui Shaw BSc PhD Group Leader and Professor of Translational Cancer Genetics, Leicester University
Professor James Spicer FRCP, PhD Professor of Experimental Cancer Medicine, King’s College London; Consultant in Medical Oncology, Guy’s & St Thomas’ NHS Foundation trust
Professor Nigel Stallard Professor of Medical Statistics, Deputy Director Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry
Professor Kevin M G Taylor BPharm PhD FRPharmS Emeritus Professor of Clinical Pharmaceutics, UCL School of Pharmacy, London
Professor Robert W. Taylor PhD DSc FRCPath Professor of Mitochondrial Pathology, Mitochondrial Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University Head, Highly Specialised Mitochondrial Laboratory, Newcastle upon Tyne Hospitals NHS Foundation Trust, Scientific Director, North East and Yorkshire Genomic Laboratory Hub Chair, Association for Clinical Genomic Science
Dr Robin Thorpe BSc PhD FRCPath Retired, Head, Division of Biotherapeutics, National Institute for Biological Standards and Control (NIBSC)
Dr David Turner PhD FRCPath H&I Laboratory, Scottish National Blood Transfusion Service, Royal Infirmary of Edinburgh
Professor Marc Turner MBBS PhD MBA FRCP FRCPath FHEA Professor of Cellular Therapy; Medical Director Scottish National Blood Transfusion Service
Professor Christopher Weir BSc MSc PhD FRSS Cstat Professor of Medical Statistics & Clinical Trials, Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh
Professor Anthony Williams BSc MSc MRCP, FRCPath, PhD Professor of Translational Medicine and Honorary Consultant in Clinical Immunology and Allergy, University of Southampton and University Hospital Southampton NHS Trust
Professor Christopher Yau MA MEng DPhil Professor of Artificial Intelligence, Nuffield Department of Women’s & Reproductive Health, University of Oxford and Health Data Research UK
Professor Ly-Mee Yu BSc MSc DPhil Professor of Clinical Trials and Biostatistics, Deputy Director Academic of Primary Care Clinical Trials Unit, Nuffield Department of Primary Care Health Sciences, University of Oxford
Observers
Professor Peter Johnson National Clinical Director for Cancer, England
Dr Jayne Spink Prostate Cancer Research