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Research and analysis

COVID-19: PHE laboratory assessments of inactivation methods

PHE has undertaken assessments of inactivation methods against SARS-CoV-2 with further evaluations ongoing.

From:
Public Health England
Published:
8 July 2020
Last updated:
4 May 2021 — See all updates

Documents

HCM-CoV2-077-v1_DiaSorin_LIAISON_SARS-CoV-2 Ag_Inactivation_Buffer_TCF

Ref: GW-8122

PDF, 149 KB, 5 pages

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HCM-CoV2-076-v1 Mologic_COVID_19_Rapid_Antigen_Test _(Swab)_Buffer_TCF

Ref: GW-8122

PDF, 118 KB, 4 pages

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HCM-CoV2-075-v1_Hypochlorous_Acid_F_K_Holdings_TCF

Ref: GW-8122

PDF, 133 KB, 4 pages

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HCM-CoV2-074-v1_ScheBo_SARS_CoV_2_Quick_Antigen_Extraction_Buffer_TCF

Ref: GW-8122

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HCM-CoV2-073-v1_Zeesan_Saliva_RNA_Sample_Collection_Kit_buffer_TCF

Ref: GW-8122

PDF, 119 KB, 4 pages

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HCM-CoV2-072-v1_LGC_Salicovgel- TCF

Ref: GW-8122

PDF, 119 KB, 4 pages

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HCM-CoV2-071-v2_GeneMe_SAVD_Buffer_TCF

Ref: GW-8122

PDF, 131 KB, 5 pages

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HCM-CoV2-070-v1_GeneMe_FRANKD_Buffer_TCF

Ref: GW-8122

PDF, 116 KB, 4 pages

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HCM-CoV2-061-v2 Novacyt_PROmate_Sample_Preparation_Buffer _Triton_X_100_(standard)_TCF

PDF, 118 KB, 4 pages

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HCM/CoV2/068/v1 MELT V4 Buffer

Ref: PHE publications gateway number GW-1859

PDF, 212 KB, 4 pages

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HCM/CoV2/067/v1 MELT V3 Buffer

Ref: PHE publications gateway number GW-1859

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HCM/CoV2/066/v2 Veritor Extraction Reagent

Ref: PHE publications gateway number GW-1859

PDF, 216 KB, 4 pages

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HCM/CoV2/065/v1 Salicovgel-1

Ref: PHE publications gateway number GW-1859

PDF, 212 KB, 4 pages

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HCM/CoV2/064/v1 MicroLYSIS-RNA Direct to PCR Lysis Solution

Ref: PHE publications gateway number GW-1859

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HCM/CoV2/063/v1 ID NOW COVID-19 Elution Buffer

Ref: PHE publications gateway number GW-1859

PDF, 215 KB, 4 pages

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HCM/CoV2/062/v1 taco Sample Storage Solution

Ref: PHE publications gateway number GW-1859

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HCM-CoV2-061-v2 Novacyt_PROmate_Sample_Preparation_Buffer _Triton_X_100_(standard)_TCF

Ref: GW-8122

PDF, 115 KB, 4 pages

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HCM-CoV2-060-v2_Novacyt_PROmate_Sample_Preparation_Buffer_(Triton X-100 reduced)_TCF

Ref: GW-8122

PDF, 115 KB, 4 pages

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HCM/CoV2/059/v1 virusPHIX-P9

Ref: PHE publications gateway number GW-1859

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HCM/CoV2/058/v1 MELT V1

Ref: PHE publications gateway number GW-1859

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HCM/CoV2/057/v1 virusPHIX-CU

Ref: PHE publications gateway number GW-1859

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HCM/CoV2/056/v1 ESPLINE SARS-CoV-2 Sample Extraction Solution

Ref: PHE publications gateway number GW-1859

PDF, 214 KB, 4 pages

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HCM-CoV2-055-v1 VirusPHIX-LV

Ref: PHE publications gateway number GW-1725

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HCM-CoV2-054-v1 Biomonde Lysis Buffer

Ref: PHE publications gateway number GW-1725

PDF, 361 KB, 4 pages

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HCM-CoV2-053-v1 Deepblue COVID-19 Antigen Test Extraction Reagent

Ref: PHE publications gateway number GW-1725

PDF, 352 KB, 4 pages

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HCM-CoV2-052-v1 Orient Gene Coronavirus Ag Rapid Test Buffer

Ref: PHE publications gateway number GW-1725

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HCM-CoV2-051-v1 70% Acetone

Ref: PHE publications gateway number GW-1859

PDF, 242 KB, 5 pages

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HCM-CoV2-050-v1 70% Isopropanol

Ref: PHE publications gateway number GW-1859

PDF, 228 KB, 4 pages

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HCM-CoV2-049-v1 Abbott Panbio COVID-19 Rapid Test Device Buffer

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HCM-CoV2-048-v1 Innova Extraction Solution

Ref: PHE publications gateway number GW-1725

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HCM-CoV2-047-v1 Standard Q COVID-19 Ag Saliva Extraction Buffer

Ref: PHE publications gateway number GW-1725

PDF, 353 KB, 4 pages

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HCM-CoV2-046-v2 VitaPCR Buffer

Ref: PHE publications gateway number GW-1725

PDF, 371 KB, 5 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/045/v2 LumiraDx

Ref: PHE publications gateway number: GW-1694

PDF, 186 KB, 4 pages

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HCM-CoV2-044-v1 1% Virkon

Ref: PHE publications gateway number GW-1725

PDF, 356 KB, 4 pages

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HCM-CoV2-043-v3 Ethanol TCF

Ref: PHE publications gateway number GW-1859

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HCM-CoV2-042-v1 Zeesan Biotech Buffer 401108

Ref: PHE publications gateway number GW-1725

PDF, 356 KB, 4 pages

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HCM-CoV2-041-v1 Zeesan Biotech Buffer 401120

Ref: PHE publications gateway number GW-1725

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HCM-CoV2-040-v2 D-Biotech

Ref: PHE publications gateway number GW-1725

PDF, 376 KB, 5 pages

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HCM-CoV2-039-v2 Omnigene

Ref: PHE publications gateway number GW-1725

PDF, 356 KB, 4 pages

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HCM/CoV2/038/v4 Standard Q COVID-19 Ag Extraction Buffer

Ref: PHE publications GW-1859

PDF, 219 KB, 4 pages

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HCM-CoV2-037-v2 Arcis Buffer

Ref: PHE publications gateway number GW-1725

PDF, 381 KB, 5 pages

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HCM-CoV2-036-v3 GeneFix Buffer

Ref: PHE publications gateway number GW-1725

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HCM-CoV2-035-v3 BuccalFiX Buffer

Ref: PHE publications gateway number GW-1725

PDF, 357 KB, 4 pages

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HCM-CoV2-034-v2 virusPHIX

Ref: PHE publications gateway number GW-1725

PDF, 378 KB, 5 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/033/v1 EO Lysis Buffer

Ref: PHE publications gateway number: GW-1464

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/032/v1 EO VPSS

Ref: PHE publications gateway number: GW-1464

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-031-v1 PHMB

Ref: PHE publications gateway number: GW-1464

PDF, 201 KB, 5 pages

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-030-v1 Copan eNAT

Ref: PHE publications gateway number: GW-1464

PDF, 208 KB, 5 pages

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-029-v2 MELT Medium B

Ref: PHE publications gateway number: GW-1464

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-028-v1 MELT Medium A

Ref: PHE publications gateway number: GW-1464

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-027-v1 Vstrip Extraction Buffer

Ref: PHE publications gateway number: GW-1464

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-026-v1 Samba SCoV Buffer

Ref: PHE publications gateway number: GW-1464

PDF, 188 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-025-v1 NP40

Ref: PHE publications gateway number: GW-1464

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-024-v1 SDS

Ref: PHE publications gateway number: GW-1464

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/023/v1 Triton™ X-100

Ref: PHE publications gateway number GW-1373

PDF, 324 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/022/v1 Virus Transport and Preservation Medium (Inactivated)

Ref: PHE publications gateway number GW-1373

PDF, 326 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/021/v1 NeuMoDx™ Viral Lysis Buffer

Ref: PHE publications gateway number GW-1373

PDF, 323 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-019-v3 4M GITC

Ref: PHE publications gateway number: GW-1464

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/019/v2 GITC 4M Transport Medium

Ref: PHE publications gateway number GW-1373

PDF, 332 KB, 5 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/018/v2 AVL + ethanol TCF

Ref: PHE publications gateway number GW-1373

PDF, 324 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/017/v2 MagNA Pure 96 External Lysis Buffer

Ref: PHE publications gateway number GW-1373

PDF, 323 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/016/v2 PrimeStore Molecular Transport Medium (MTM)

Ref: PHE publications gateway number GW-1373

PDF, 325 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/015/v2 cobas® Omni LYS reagent

Ref: PHE publications gateway number GW-1373

PDF, 325 KB, 4 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/014/v3 GHCl 40% (w/v) Transport Medium

Ref: PHE publications gateway number GW-137

PDF, 331 KB, 5 pages

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/013/v3 GITC 2M Transport Medium

Ref: PHE publications gateway number GW-1373

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/012/v2 Buffer AVL

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SARS-CoV-2 inactivation testing: interim report HCM-CoV2-009-v3 Heat Treatment

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SARS-CoV-2 inactivation testing: interim report HCM/CoV/008/v3 Buffer RLT + 1% β-mercaptoethanol

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/007/v2 Aptima® Specimen Transport Medium

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/006/v3 Triton™ X-100

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/005/v3 Tween® 20 (synonym: polysorbate 20)

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/004/v3 Cobas® PCR Media

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/003/v4 Panther Fusion™ Specimen Lysis Tubes

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SARS-CoV-2 inactivation testing: interim report HCM/CoV2/002/v4 Sigma MM™

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SARS-CoV-2 inactivation testing: interim report HCM/CoV/001/v4 Nuclisens® Lysis Buffer

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Details

Public Health England (PHE) has undertaken assessments of inactivation methods against SARS-CoV-2.

Included here are a series of individual interim inactivation reports with further evaluations ongoing.

These reports will be useful for COVID-19 testing laboratories developing workflows that include an inactivation step and will aid the generation of suitable and sufficient risk assessments.

These assessments are now published by UK Health Security Agency.

Updates to this page

Published 8 July 2020
Last updated 4 May 2021 Show all updates

  1. Added 11 SARS-CoV-2 inactivation testing interim reports.

  2. Added 12 new reports and updated 043, 050 and 051.

  3. Added updated version of 'HCM-CoV2-043-v3 Ethanol TCF'.

  4. Added reports 34 to 55.

  5. Added 2 SARS-CoV-2 inactivation testing interim reports.

  6. Added 12 SARS-CoV-2 inactivation testing interim reports.

  7. First published.

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