Development of experimental approaches for determining concentrations of antifungals that select for resistance
Looks at methods for the determination of the lowest concentration of antifungals that can lead to a selective advantage for resistant organisms.
Applies to England
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This project looked at methods for the determination of the lowest concentration of antifungals that can lead to a selective advantage for resistant organisms.
When natural microbial communities are exposed to antimicrobial substances any strain that can resist the harmful effects can come to dominate the population by simply growing and reproducing faster than its neighbours. Hence, exposure to antimicrobials in the environment can result in selection for resistance in the microbial community. The concentration of a substance at which selection for resistance may occur has been studied in antibiotics, but there is limited work on antifungals.