FOI release

Freedom of Information request (FOI 22/1022)

Published 17 January 2024

20th December 2022

FOI 22/1022

Dear

Thank you for your reply, and apologies for the oversight, we were under the impression a response had been sent.

Our reference data team, have replied stating the following, there are no (market authorisations) MAs for any of these combinations.

The team have also double-checked if there have been any withdrawn or refused applications for the same list of products*, and have confirmed there are none.

Antipsychotic

Chlorpromazine + trifluoperazine + trihexyphenidyl

Chlorpromazine + trihexyphenidyl

Flupentixol + escitalopram

Flupentixol + melitracen

Haloperidol + trihexyphenidyl

Olanzapine + fluoxetine

Risperidone + trihexyphenidyl

Thioridazine + trihexyphenidyl

Thioridazine + trifluoperazine + trihexyphenidyl

Trifluoperazine + chlordiazepoxide

Trifluoperazine + chlordiazepoxide + trihexyphenidyl

Trifluoperazine + imipramine + chlordiazepoxide + trihexyphenidyl

Trifluoperazine + trihexyphenidyl

Antidepressant

Amitriptyline + chlordiazepoxide

Desvenlafaxine + clonazepam

Duloxetine + methylcobalamin

Duloxetine + pregabalin

Escitalopram + clonazepam

Escitalopram + etizolam

Escitalopram + L-methylfolate

Fluoxetine + alprazolam

Imipramine + alprazolam

Imipramine + chlordiazepoxide

Imipramine + diazepam

Paroxetine + clonazepam

Sertraline + alprazolam

Benzodiazepine/sedative

Alprazolam + mebeverine

Alprazolam + melatonin

Alprazolam + propranolol

Chlordiazepoxide + clidinium

Chlordiazepoxide + clidinium + dicyclomine

Chlordiazepoxide + clidinium + dicyclomine + rabeprazole

Chlordiazepoxide + clidinium + pantoprazole

Chlordiazepoxide + mebeverine

Clonazepam + propranolol

Diazepam + dicyclomine

Diazepam + magaldrate + oxyphenonium

Diazepam + propranolol

Etizolam + propranolol

Melatonin + zolpidem

If you disagree with how we have interpreted the Freedom of Information Act 2000 with regards to your request, you can ask for the decision to be reviewed. The review will be carried out by a senior member of the Agency who was not involved with the original decision.

If you have a query about the information provided, please reply to this email If you are dissatisfied with the handling of your request, you have the right to ask for an internal review. Internal review requests should be submitted within two months of the date you receive this response and addressed to: info@mhra.gov.uk.

If you were to remain dissatisfied with the outcome of the internal review, you would have the right to apply directly to the Information Commissioner for a decision. Please bear in mind that the Information Commissioner will not normally review our

handling of your request unless you have first contacted us to conduct an internal review. The Information Commissioner can be contacted at:

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Wycliffe House Water Lane Wilmslow Cheshire SK9 5AF

Please remember to quote the reference number above in any future communications.

Kind regards,

HQA FOI Team