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Non-tech. summaries 2014: projects on multisystemic research

Projects granted during 2014 that have a primary purpose of basic research: multisystemic.

• From: Home Office
• Published: 25 April 2016

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Non-technical summaries: projects granted in 2014, volume 16

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Details

This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2014 with a primary purpose of basic research: multisystemic.

The following projects were granted:

• role of G protein-coupled receptors behaviour and homeostasis (G protein-coupled receptors, behaviour, homeostasis, vasopressin, apelin)

• medical countermeasures to dangerous pathogens (medical countermeasures, infection, protection, defence)

• generation and maintenance of transgenic mice (transgenics, microinjection, mice, genetics)

• therapeutic target validation in fibrosis (fibrosis, signalling pathways, drug targets)

• nutrition and lactation in ruminants (ruminant, nutrition, lactation, metabolism, rumen function)

• breeding and typing of genetically altered mice (mouse, DNA binding proteins, signalling pathway, knockout, transgenic)

• methods and tools for mouse genome engineering (mouse transgenesis method development refinement)

• determining pathways that regulate lung inflammation (lung inflammation, injury, fibrosis)

• electrical stimulation of muscle and research in alkaptonuria (muscle, activity, alkaptonuria)

• centrosome biology in mammalian development, aging and stem cell function (development, stem cells, aging, cell division)

• the mechanisms underlying mammalian obesity and type 2 diabetes (insulin resistance, diabetes, obesity, cognitive defects, metabolism)

• neurobiology and inflammatory mechanisms (sensory nerves, cardiovascular, inflammation, neurobiology)

• fumarate hydratase in cancer biology and metabolism (fumarate hydratase, cancer, metabolism, diabetes)

• in vivo study of sound transmission to the third trimester fetus (fetus, ear, sound, in-utero, pregnancy)

• studies to investigate laminitis predisposition (horse, laminitis, endothelium, insulin, metabolic)

• the influence of barometric pressure changes upon membrane physiology and xenobiotic penetration (air pressure, penetration of drugs, skin, blood flow)

• pre-clinical mouse models of human ciliopathies (embryogenesis, development, cilium, ciliopathies)

• epigenetic reprogramming in mammalian development (epigenetics, methylation, germ cells, embryos, diet)

• management of genetically altered rodent lines (genetic alteration embryo stem cell)

• pathophysiological roles of podoplanin and its receptor CLEC-2 (podoplanin, CLEC -2, embryogenesis, vascular integrity)

Published 25 April 2016