Transparency data

Non-tech. summaries 2015: projects on multisystemic research

Projects granted during 2015 that have a primary purpose of multisystemic research.

From:
Home Office
Published
28 June 2016

Documents

Non-technical summaries: projects granted in 2015, volume 27

PDF, 837 KB, 131 pages

This file may not be suitable for users of assistive technology.

Request an accessible format.
If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email alternativeformats@homeoffice.gov.uk. Please tell us what format you need. It will help us if you say what assistive technology you use.

Details

This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2015 with a primary purpose of multisystemic research.

The following projects were granted:

  • molecular basis of vertebrate development (mouse, DNA binding proteins, signalling pathway, knockout, transgenic)

  • genetics of behaviour and stress response in fish (genetics, stress, evolution, fish, behaviour)

  • brain mechanisms regulating cardiovascular homeostasis in health and disease (brain, mechanisms, regulating, cardiovascular homeostasis, health, disease)

  • breeding, freezing and recovering genetically modified mice (breeding, freezing, genetically modified, mice)

  • mechanisms of stem cell differentiation in fish (transgenic fish, embryo development, gene function)

  • pre-treatment and monitoring of the organ donor to improve graft function for transplantation (donation, transplant, kidney, liver, ischemia)

  • in vivo studies of ADP-ribosylation signalling (ADP-ribosylation, post-translational modification (PTM))

  • health of aged cloned sheep (health, aged, cloned, sheep)

  • functional analysis of factors implicated in X chromosome inactivation (gene regulation, X chromosome, chromatin)

  • pathways of gut health and inflammation (gut, ageing, inflammation, microorganisms)

  • organ dysfunction following acute illness (intensive care, sepsis, organ failure)

  • DNA Strand Breaks, DNA damage responses, and disease (DNA damage, neurodegeneration, cancer)

  • study of changes which occur during ageing (healthy ageing connective tissue crosslinks)

  • models of viral hepatitis (hepatitis, virus, treatment)

  • oxidative stress and ageing (oxidative stress, degenerative disease, ageing)

  • mouse membrane traffic mutants (basic science, human disease)

  • genetic analysis of stem cells using the mouse (stem cells, mouse, genetics)

  • breeding and production of genetically altered mice (genetic alteration, mouse, breeding)

  • investigation of the in vivo action of G protein coupled receptors (neurodegeneration, physiology, drugs, cancer, diabetes)

  • cell signalling in neural and cardiovascular development and regeneration (blood vessel growth, nerve regeneration)

  • study of infection and antibiotic resistance (antibiotics, bacteria, resistance)

  • regulation of mammalian hox genes (mouse, hox, gene regulation, enhancer elements)

  • DNA damage response involvement in genome stability and cancer (DNA damage, genome stability, cancer)

  • molecular regulation of development (development, zebrafish, embryo, mechanism)

  • investigating the pharmacology of traditional and nanoformulated medicines (pharmacokinetics, nanoformulation, bioavailability, tissue distribution)

  • utilising MRI to probe physiological state (MRI, contrast agent, diagnosis, disease)

  • podoplanin-CLEC-2 in sepsis and haemolytic uremic syndrome (CLEC-2, podoplanin, sepsis, HUS)

  • fungal infection, diagnosis and therapy (fungus, infection, anti-fungal, therapy, diagnosis)

  • nuclear reprogramming by xenopus eggs and oocytes (nucleus, reprogramming, xenopus)

  • complex mammalian responses to alkylating agents (DNA damage, DNA repair, metabolism, alkylation)

  • polyclonal antibody development (polyclonal, antibody, immunisation, rabbit, sheep)

  • mechanism underlying diet induced metabolic disorders (high fructose, high fat, sucrose, ketohexokinase, NAFLD)

  • pathophysiology of the unfolded protein response (protein misfolding, endoplasmic reticulum, unfolded protein response protein chaperones, diseases of ageing

  • immunobiology of mycobacterial infection (tuberculosis, mycobacterium, vaccines, chemotherapy)

  • understanding how parasitic worms (roundworms) have evolved and developing new drugs to treat diseases caused by them (parasite, trichinella, novel drugs, anthelmintics)

  • immune regulation of tissue repair in ageing (immunity, senescence, ageing)

  • control of central nervous system autoimmunity (multiple sclerosis, neuroprotection, repair, autoimmunity, spasticity)

  • studying macrophage plasticity in inflammatory disease (macrophages, inflammatory disease, genomics/genetics)

  • regulation of cell polarity in vertebrate development (embryo, development, cells, regenerative medicine)

  • treatment of abnormal retinal development (mice, albinism, L-DOPA, treatment, vision)

  • blocking senescence in ageing (ageing)

Updates to this page

Published 28 June 2016

Sign up for emails or print this page

Related content