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Non-tech. summaries 2015: projects on the nervous system

Projects granted during 2015 with a primary purpose of basic research: nervous system.

• From: Home Office
• Published: 24 June 2016

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Non-technical summaries: projects granted in 2015, volume 19

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This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2015 with a primary purpose of basic research: nervous system.

The following projects were granted:

• brain plasticity with experience and recovery (plasticity, learning, stroke, exercise, experience)

• neuronal network activity underlying behaviour (brain, neuron, plasticity, cognition, neuromodulator)

• neural mechanisms in health and disease (neurophysiological function, neurophysiological dysfunction, ageing)

• circuit mechanisms governing network oscillations (septum, cortex, oscillations, theta, synapses)

• affect and cognition in rodents (affect, cognition, consumption, microstructure)

• role of neuroinflammation in depression and cognition (depression, inflammation, inflammasome)

• genetically modified rodent models of neurodegeneration (alzheimer’s; parkinson’s, motor neuron disease; transgenic rodents; novel therapeutics)

• delta-protocadherins in cortical development (cortex, development, delta-2 protocadherins, Pcdh19, EFMR)

• plasticity and function of the visual system (primary visual cortex; amblyopia; neurodevelopmental disorders; glaucoma)

• brain systems for rodent memory (brain, systems, rodent, memory)

• genetic and functional studies in neurodegenerative disease (neurodegeneration, alzheimer disease, down syndrome, motor neuron diseases, mouse)

• drug modification of opioid tolerance (opioid: tolerance: respiratory depression)

• novel imaging applied to the study of memory (learning, memory, imaging, synaptic plasticity, optics)

• bioenergetics of the nervous system (bioenergetics, mitochondria, inflammation, demyelination, neurodegeneration)

• support procedures for neuroscience studies (transgenic, behaviour, substances, tissue)

• neuropharmacology of vulnerability to compulsivity (addiction, compulsivity, vulnerability, neuropharmacology, rat)

• rodent models of neurodegenerative disease (huntington’s disease, cognition, locomotion, mice)

• spinal cord injury and repair (spinal cord; plasticity; regeneration; rehabilitation)

• mechanisms of myelination and synapse formation (epilepsy, neuropathy, genetic programme)

• blood vessels in cortical interneuron development (neocortex, interneurons, development, migration, blood vessels)

• neurophysiology of reward (brain1 neurons, reward, learning, decision making)

• investigating the neural basis of spatial and episodic memory (memory, episodic, alzheimer’s, hippocampus, behaviour)

• epigenetic regulation of neuronal development (brain, development, neurodegeneration, transcription)

• neuronal networks and pathways for communication (communication, neuroimaging, neurophysiology, primate, neuronal mechanisms)

• molecular pathogenesis of neurodegeneration (alzheimer’s O-GlcNAcylation neuropathology)

• neuronal and sensory functions of tmc genes (sensory transduction, taste, touch, hearing)

• mechanisms of perinatal brain injury (preterm, term, hypoxia-ischaemia, inflammation, translational)

• cognitive-enhancing properties of nicotine and related psychoactive substances (nicotine, attention, withdrawal, dependence)

• mechanism of brain function and malfunction (cognition, cell assemblies, EEG, dementia, transgenes)

• neuronal activity underlying sensory behaviour (brain, electrophysiology, imaging, information processing, somatosensory)

• GABAAR, neurosteroids and stress in brain function (GABA, neurotransmission, stress, depression, addiction)

• investigation of the in vivo action of G protein coupled receptors (neurodegeneration, physiology, drugs, cancer, diabetes)

• biological and psychological bases of addiction (drug abuse, transgenic mice, behaviour)

• characterisation of novel therapeutics (drug discovery)

• studying central nervous system repair (multiple sclerosis, cerebral palsy, central nervous system, repair, oligodendrocyte)

• studying myelinated axons in vivo using zebrafish (zebrafish, in vivo imaging, nervous system development)

• zebrafish models of movement disorders (parkinson’s disease, mitochondria, dopaminergic neurons, parkin, PINK1)

• post-operative cognitive decline: pathogenesis & protection (surgery; neuroinflammation; cognition; dementia; alzheimer’s)

• genetic analysis of axon guidance and maintenance (breeding, transgenic, neurodegeneration)

• analysis of fish development (eye, brain, stem cells, zebrafish)

• blood flow and tissue oxygenation in rodents (haemodynamic response, imaging, pre-clinical models)

• biological and psychological bases for addictions (drug abuse, transgenic mice, behaviour)

• molecular & cellular correlates of stress-induced behaviour (GABA, mental illness, noradrenaline, serotonin, emotion)

• neuronal circuitry of the spinal dorsal horn (pain, itch, spinal cord, interneuron, projection neuron)

• cellular functions of myosin motor proteins (cell function, neurodegeneration, transport)

• perioperative medicine related uses of anaesthetics (rodent; anaesthetics, noble gas; brain injury; cancer)

• cerebrovascular changes in the aged and diseased brain (ageing, alzheimer’s disease, blood vessel)

• synaptic plasticity in normal learning and addiction (memory, hippocampus, accumbens, opioid, heroin)

• misfolded protein and neurodegenerative disease (prion, amyloid, seeding, neurodegeneration, TSE)

• neuronal and glial AMPA and GABAA receptors in health and disease (synaptic transmission; neurons: neurological disease)

• studies to find improved treatments for movement disorders (parkinson’s disease dystonia neurodegeneration neuroprotection symptomatic treatment)

• neurovascular coupling in health ageing and disease (neurovascular coupling, dementia, ageing, epilepsy)

• animal models of neurodevelopmental disorders (rat, behaviour, pregnancy, gut, brain)

• antibodies to neuropeptidergic signalling molecules (antibody neuropeptide evolution echinoderm)

• basic mechanisms of chronic neurodegeneration (TSE, neurodegeneration, mouse models)

• connectivity and plasticity of developing and mature central nervous system circuits (brain development, neurons, synapses, axons)

• structural and functional plasticity in cortex (brain, plasticity, degeneration, synapses, learning)

• studying a human neurological disease-causing gene (epilepssy, motor neuron disease, autism)

• spinal sensory processing (somatosensory, dorsal root ganglion, spinal, analgesia)

• the role of neuropeptides in behaviour (vasopressin, oxytocin, social behaviours)

• memory in the rat (memory, learning)

• neural basis on spatial learning and memory (neural, spatial, learning, memory)

• the neural basis of spatial cognition and memory (rat, mouse, single neurons, behaviour, spatial memory, navigation)

• mechanisms contributing to analgesic use & misuse (opioid, GABA, neurotransmission, stress, nociception)

• functions of the murine trappc9 gene (brain development, stem cells, microcephaly)

• mechanism-based targets for new analgesics (analgesia, molecular targets, somatosensory, sensitisation)

• encoding behaviour from synapses to circuits (behaviour, neurons, communication, brain, experience)

• understanding successful brain repair in zebrafish (traumatic brain injury, tissue repair)

• ion channel function and epileptogenesis (ion channels, epilepsy, brain)

• neuroprotective treatments for traumatic injury (neuroprotection, spinal cord injury, regeneration, nerve injury, repair)

• repairing the damaged peripheral nerve (sciatic nerve, axon regeneration, neuroprotection, scarring, nerve conduits)

• cell-specific chromatin profiling in mouse cortex (cerebral cortex development; targeted DamID)

• the role of central sympathetic control neurones (cardiovascular control, paraventricular nucleus)

• the molecular and cellular mechanisms that underpin cns plasticity (stem cells, myelin, regeneration)

• recovery of peripheral nerve function (nerve, bladder, physiology)

Published 24 June 2016