Research and analysis
NOIDs causative agents: week 46 (week ending 19 November 2023)
Updated 2 January 2024
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Laboratories in England have a statutory duty to notify the UK Health Security Agency (UKHSA) of the identification of the following causative agents:
- Bacillus anthracis
- Bacillus cereus
- Bordetella pertussis
- Borrelia spp
- Brucella spp
- Burkholderia mallei
- Burkholderia pseudomallei
- Campylobacter spp
- Carbapenemase-producing Gram-negative bacteria
- Chikungunya virus
- Chlamydophila psittaci
- Clostridium botulinum
- Clostridium perfringens
- Clostridium tetani
- Corynebacterium diphtheriae
- Corynebacterium ulcerans
- Coxiella burnetii
- Crimean-Congo haemorrhagic fever virus
- Cryptosporidium spp
- Dengue virus
- Ebola virus
- Entamoeba histolytica
- Escherichia coli O 157
- Francisella tularensis
- Giardia lamblia
- Guanarito virus
- Haemophilus influenzae (invasive)
- Hanta virus
- Hepatitis A
- Hepatitis B
- Hepatitis C
- Hepatitis D
- Hepatitis E
- Influenza virus
- Junin virus
- Kyasanur Forest disease virus
- Lassa virus
- Legionella spp
- Leptospira interrogans
- Listeria monocytogenes
- Machupo virus
- Marburg virus
- Measles virus
- Mpox (monkeypox) virus
- Mumps virus
- Mycobacterium tuberculosis complex
- Neisseria meningitidis
- Omsk haemorrhagic fever virus
- Plasmodium falciparum
- Plasmodium knowlesi
- Plasmodium malariae
- Plasmodium ovale
- Plasmodium vivax
- Polio virus
- Rabies virus
- Rickettsia spp
- Rift Valley fever virus
- Rubella virus
- Sabia virus
- Salmonella spp
- SARS coronavirus
- Shigella spp
- Streptococcus group A (invasive)
- Streptococcus pneumoniae (invasive)
- Varicella zoster virus
- Variola virus
- Vibrio cholerae
- West Nile virus
- Yellow fever virus
- Yersinia pestis
Statutory notifications of causative agents, grouped by root organism
Totals for the current week compared to the previous 5.
| Week notification received | 2023/41 | 2023/42 | 2023/43 | 2023/44 | 2023/45 | 2023/46 |
|---|---|---|---|---|---|---|
| Bacillus | ||||||
| Bacillus cereus | 29 | 34 | 18 | 21 | 13 | 16 |
| Bordetella | ||||||
| Bordetella pertussis | 14 | 8 | 12 | 10 | 12 | 14 |
| Borrelia | ||||||
| Borrelia burgdorferi | 52 | 39 | 40 | 36 | 17 | 14 |
| Borrelia sp | 11 | 3 | 5 | 7 | 7 | 4 |
| Brucella | ||||||
| Brucella melitensis | - | - | - | 1 | - | - |
| Brucella sp | - | - | - | - | 2 | - |
| Burkholderia | ||||||
| Burkholderia pseudomallei | - | - | - | - | - | 1 |
| Campylobacter | ||||||
| Campylobacter coli | 46 | 28 | 36 | 32 | 27 | 31 |
| Campylobacter gracilis | - | 1 | - | - | - | - |
| Campylobacter jejuni | 334 | 240 | 303 | 283 | 303 | 277 |
| Campylobacter other named | 4 | - | 2 | 2 | - | 1 |
| Campylobacter sp | 975 | 1,105 | 1,047 | 1,013 | 971 | 1,079 |
| Campylobacter upsaliensis | - | 2 | 1 | 2 | - | 2 |
| Campylobacter ureolyticus (bacteroides corrodens) | - | 1 | 3 | - | 1 | - |
| Chikungunya virus | ||||||
| Chikungunya virus | - | 1 | 2 | 2 | - | 1 |
| Clostridium | ||||||
| Clostridium perfringens | 26 | 24 | 19 | 25 | 21 | 38 |
| Clostridium tetani | - | 1 | 1 | - | - | - |
| Coronavirus | ||||||
| Coronavirus | 16 | 22 | 20 | 14 | 18 | 14 |
| Human coronavirus 229e | - | - | - | - | - | 1 |
| SARS-CoV-2 antibody indeterminate | 126 | 114 | 133 | 129 | 105 | 120 |
| SARS-CoV-2 antibody void | 8 | 2 | 6 | 2 | 2 | 2 |
| SARS-CoV-2 coronavirus (COVID-19) | 12,031 | 8,837 | 6,894 | 5,849 | 3,889 | 4,430 |
| SARS-CoV-2 coronavirus (COVID-19) indeterminate | 124 | 167 | 97 | 70 | 57 | 55 |
| SARS-CoV-2 IgG antibody negative | 60 | 58 | 25 | 41 | 41 | 36 |
| SARS-CoV-2 IgG antibody positive | 207 | 236 | 163 | 158 | 191 | 177 |
| SARS-CoV-2 total antibody negative | 105 | 49 | 60 | 43 | 33 | 66 |
| SARS-CoV-2 total antibody positive | 260 | 145 | 139 | 116 | 94 | 108 |
| Corynebacterium | ||||||
| Corynebacterium diphtheriae | - | 2 | 1 | 8 | 1 | 1 |
| Corynebacterium ulcerans | - | - | 1 | - | - | 1 |
| Cryptosporidium | ||||||
| Cryptosporidium cuniculus | 1 | 1 | - | - | 1 | - |
| Cryptosporidium felis | - | 2 | - | - | - | - |
| Cryptosporidium hominis | 193 | 128 | 101 | 87 | 108 | 54 |
| Cryptosporidium parvum | 88 | 66 | 55 | 41 | 60 | 22 |
| Cryptosporidium sp | 93 | 155 | 89 | 107 | 75 | 198 |
| Cryptosporidium ubiquitum | 1 | - | 1 | - | - | - |
| Cryptosporidium viatorum | - | - | - | 1 | - | - |
| Entamoeba | ||||||
| Entamoeba histolytica | - | 2 | 1 | - | 1 | 1 |
| Escherichia | ||||||
| Escherichia coli O 157 | 20 | 38 | 23 | 17 | 12 | 12 |
| Flaviviruses | ||||||
| Dengue virus | 6 | 2 | 6 | 2 | 2 | 4 |
| Haemophilus | ||||||
| Haemophilus influenzae | 61 | 54 | 59 | 61 | 73 | 79 |
| Hepatitis viruses | ||||||
| Hepatitis A | 22 | 22 | 14 | 13 | 13 | 9 |
| Hepatitis B | 330 | 299 | 314 | 312 | 262 | 286 |
| Hepatitis C | 282 | 274 | 275 | 240 | 206 | 288 |
| Hepatitis D | 8 | 6 | 10 | 6 | 3 | 20 |
| Hepatitis E | 33 | 29 | 37 | 20 | 28 | 24 |
| Influenza virus | ||||||
| Influenza A | 130 | 122 | 151 | 205 | 246 | 314 |
| Influenza B | 70 | 50 | 50 | 62 | 78 | 68 |
| Influenza indeterminate | - | - | - | - | - | 1 |
| Influenza ungrouped | - | 5 | 2 | 17 | 4 | 10 |
| Legionella | ||||||
| Legionella longbeachae | - | - | - | 1 | - | - |
| Legionella pneumophila | 10 | 6 | 7 | 5 | 4 | 7 |
| Legionella sp | 4 | 3 | 4 | 3 | 5 | 3 |
| Listeria | ||||||
| Listeria monocytogenes | 5 | 6 | 4 | 6 | 4 | 4 |
| Mycobacterium | ||||||
| Mycobacterium tuberculosis | 97 | 70 | 85 | 71 | 63 | 80 |
| Neisseria | ||||||
| Neisseria meningitidis | 20 | 32 | 19 | 25 | 26 | 33 |
| Orthopoxvirus | ||||||
| Mpox virus | 3 | 6 | 2 | 20 | 8 | 10 |
| Paramyxoviruses | ||||||
| Measles virus | 5 | 3 | 3 | 3 | 6 | 10 |
| Mumps virus | 8 | - | 4 | 5 | 4 | 7 |
| Plasmodium | ||||||
| Plasmodium falciparum | 19 | 15 | 8 | 1 | - | 16 |
| Plasmodium malariae | - | 1 | - | - | - | - |
| Plasmodium ovale | 2 | 1 | 3 | - | - | 3 |
| Plasmodium vivax | 3 | 2 | 2 | - | - | 3 |
| Polyomavirus | ||||||
| Polyomavirus BK | 87 | 53 | 48 | 45 | 55 | 74 |
| Polyomavirus JC | 11 | 11 | 8 | 6 | 5 | 11 |
| Polyomavirus untyped | 19 | 25 | 15 | 18 | 12 | 15 |
| Rickettsia | ||||||
| Rickettsia spotted fever | - | - | - | 2 | - | - |
| Rubella virus | ||||||
| Rubella virus | 2 | 6 | 1 | 6 | 1 | 5 |
| Salmonella | ||||||
| Other salmonellas | 81 | 53 | 61 | 64 | 42 | 26 |
| Salmonella agona | - | 6 | - | - | - | - |
| Salmonella bareilly | - | 7 | - | - | - | - |
| Salmonella braenderup | - | 5 | - | - | - | - |
| Salmonella chester | 6 | 6 | 5 | - | - | - |
| Salmonella enteritidis | 104 | 103 | 57 | 72 | 48 | 23 |
| Salmonella infantis | 9 | 7 | 6 | 9 | - | - |
| Salmonella java | 8 | - | 5 | - | - | - |
| Salmonella kentucky | - | - | 6 | - | - | - |
| Salmonella newport | 7 | 10 | 7 | - | - | - |
| Salmonella oranienburg | - | 5 | - | - | - | - |
| Salmonella saint-paul | 16 | 16 | 24 | 13 | 7 | - |
| Salmonella sp | 22 | 24 | 18 | 38 | 78 | 140 |
| Salmonella stanley | 10 | 10 | 7 | 8 | - | - |
| Salmonella thompson | 5 | - | - | - | - | - |
| Salmonella typhi and paratyphi | 18 | 22 | 8 | 8 | 15 | 7 |
| Salmonella typhimurium | 47 | 31 | 34 | 34 | 22 | 10 |
| Salmonella virchow | - | - | 6 | - | - | - |
| Salmonella enterica | 9 | 5 | 5 | - | - | - |
| Shigella | ||||||
| Shigella boydii | - | - | 1 | 1 | 2 | 1 |
| Shigella dysenteriae | 1 | - | - | - | - | - |
| Shigella flexneri | 15 | 12 | 13 | 9 | 14 | 14 |
| Shigella sonnei | 31 | 34 | 27 | 33 | 17 | 27 |
| Shigella sp | 43 | 66 | 59 | 49 | 64 | 74 |
| Streptococcus | ||||||
| Streptococcus group A | 43 | 55 | 49 | 52 | 46 | 59 |
| Streptococcus pneumoniae | 104 | 112 | 113 | 134 | 122 | 124 |
| Vibrio | ||||||
| Vibrio cholerae | - | 3 | - | - | - | 2 |
Carbapenemase-producing Enterobacterales (CPE)
For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.
Note: the numbers presented here do not include specimens that have been referred to the AMRHAI Reference Unit.
| Week notification received | 2023/41 | 2023/42 | 2023/43 | 2023/44 | 2023/45 | 2023/46 | |
|---|---|---|---|---|---|---|---|
| Citrobacter | |||||||
| Citrobacter spp | IMP | - | - | - | - | 1 | - |
| KPC | - | 1 | 2 | 1 | 2 | - | |
| NDM | 3 | 2 | - | 4 | 3 | - | |
| OXA48 | 3 | 1 | 1 | 2 | 3 | 1 | |
| VIM | - | - | - | 1 | 2 | - | |
| Cronobacter | |||||||
| Cronobacter sakazakii | KPC | - | - | 1 | - | - | 1 |
| Other cronobacter spp | KPC | 1 | - | - | 1 | 1 | 1 |
| Enterobacter | |||||||
| Enterobacter cloacae complex | IMP | - | 3 | 3 | 3 | 3 | - |
| KPC | 9 | 6 | 7 | 14 | 10 | 3 | |
| NDM | 12 | 4 | 7 | 6 | 5 | 2 | |
| OXA48 | 5 | 1 | 2 | 1 | 3 | 3 | |
| Other | 1 | - | 1 | - | 1 | - | |
| Other enterobacter spp | NDM | 2 | - | - | - | 3 | - |
| OXA48 | 1 | - | - | - | - | - | |
| Escherichia | |||||||
| Escherichia coli | IMP | - | - | - | - | 1 | - |
| KPC | 10 | 4 | 1 | 4 | 4 | 1 | |
| NDM | 12 | 14 | 13 | 6 | 15 | 5 | |
| OXA48 | 16 | 5 | 17 | 12 | 16 | 3 | |
| VIM | - | 1 | - | - | 1 | - | |
| Other | - | 1 | 2 | 1 | - | - | |
| Escherichia hermannii | KPC | 1 | - | - | 1 | - | - |
| Escherichia vulneris | KPC | - | - | - | 1 | - | - |
| Other escherichia spp | OXA48 | - | - | - | - | 1 | - |
| Klebsiella | |||||||
| Klebsiella aerogenes | KPC | - | - | - | - | 1 | - |
| OXA48 | - | - | - | 1 | - | - | |
| Klebsiella aerogenes | Other | - | - | - | 1 | - | - |
| Klebsiella oxytoca | IMP | - | - | - | - | 1 | - |
| KPC | 7 | 5 | 8 | 3 | 5 | 2 | |
| OXA48 | 2 | 1 | 6 | - | 1 | - | |
| Klebsiella pneumoniae | IMP | - | - | - | 2 | - | - |
| KPC | 11 | 15 | 7 | 8 | 13 | 6 | |
| NDM | 8 | 8 | 7 | 9 | 8 | 1 | |
| OXA48 | 6 | 17 | 16 | 15 | 8 | 3 | |
| VIM | - | 1 | 1 | - | - | - | |
| Other | 3 | 2 | 1 | - | 1 | - | |
| Klebsiella variicola | IMP | - | - | 1 | - | - | - |
| NDM | 1 | - | - | - | - | - | |
| Other klebsiella spp | KPC | - | 1 | - | - | - | - |
| OXA48 | - | - | - | - | 1 | - | |
| Morganella | |||||||
| Morganella morganii | OXA48 | 1 | - | - | - | - | - |
| Pantoea | |||||||
| Pantoea agglomerans | KPC | - | 1 | - | - | - | - |
| Proteus | |||||||
| Proteus mirabilis | NDM | 2 | - | 2 | 2 | - | - |
| OXA48 | 1 | - | 1 | - | - | 1 | |
| Other proteus spp | OXA48 | - | - | 1 | - | - | - |
| Raoultella | |||||||
| Raoultella ornithinolytica | KPC | - | 1 | - | - | - | - |
| OXA48 | - | - | - | - | - | 1 | |
| Other raoultella spp | KPC | - | - | - | - | - | 1 |
| OXA48 | - | - | - | - | - | 1 | |
| Serratia | |||||||
| Serratia marcescens/ureilytica | NDM | - | - | 1 | - | - | - |
| Other serratia spp | NDM | - | - | - | 1 | - | - |
Other carbapenemase-producing Gram-negative organisms
For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.
Note: the numbers presented here do not include specimens that have been referred to the AMRHAI Reference Unit.
| Week notification received | 2023/41 | 2023/42 | 2023/43 | 2023/44 | 2023/45 | 2023/46 | |
|---|---|---|---|---|---|---|---|
| Acinetobacter | |||||||
| Acinetobacter baumannii | IMP | - | - | - | - | 1 | - |
| NDM | - | 1 | 1 | - | 1 | - | |
| Other | - | 1 | - | - | - | - | |
| Other acinetobacter spp | NDM | - | 1 | - | - | - | - |
| Pseudomonas | |||||||
| Pseudomonas aeruginosa | IMP | - | - | 1 | - | - | 1 |
| NDM | 1 | - | 2 | 1 | - | 1 | |
| VIM | - | 2 | 1 | - | 2 | - | |
| Other | 1 | 2 | 3 | 1 | 2 | 1 | |
| Pseudomonas koreensis | VIM | - | 1 | - | - | - | - |
| Other | - | 1 | - | - | - | - | |
| Pseudomonas putida group | NDM | - | - | - | - | 1 | - |
| VIM | - | - | - | - | 1 | - | |
| Pseudomonas stutzeri group | Other | - | 1 | - | - | - | - |
| Other | |||||||
| NDM | - | - | - | 1 | - | - |