Guidance

Statement on the COM assessment of in vitro and in vivo genotoxicity of titanium dioxide

COM position statement on the COM assessment of in vitro genotoxicity of titanium dioxide.

• From: Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment
• Published: 11 October 2024

Documents

Statement on the COM assessment of in vitro and in vivo genotoxicity of titanium dioxide

Ref: GOV-17303

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Annexe 1. Literature search strategy

Ref: GOV-17303

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Annexe 2a. Screening criteria for in vitro papers

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Annexe 2b. Screening criteria for in vivo papers

Ref: GOV-17303

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Annexe 3a. Detailed evaluation of in vitro papers with green and amber ratings

Ref: GOV-17303

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Annexe 3b. Detailed evaluation of in vivo papers with green and amber ratings

Ref: GOV-17303

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Details

This statement details the conclusions reached by the Committee on Mutagenicity (COM) regarding the published evidence on the in vitro and in vivo genotoxicity of titanium dioxide (TiO₂). This review of TiO₂ as a food additive is in response to recent evaluations by the European Food Safety Authority (EFSA) in 2016, 2019, 2021.

It includes the screening and evaluation of papers referenced in the EFSA opinion (EFSA 2021) as well as an additional literature search to identify papers published between 2021 and 2023.

Published 11 October 2024