A high oxfendazole dose to control porcine cysticercosis: Pharmacokinetics and tissue residue profiles

Article in 'Food and Chemical Toxicology'

• From: Department for International Development
• Published: 30 October 2012

• Country: Angola, Benin, Bolivia, Bulgaria, Cameroon, Chile, China, Colombia, Congo (Democratic Republic), Ecuador, El Salvador, Guatemala, Madagascar, Malawi, Mozambique, Namibia, Nicaragua, Peru, Romania, Slovenia, South Africa, Spain, Togo
• Document Type: Journal Article
• Theme: Agriculture
• Authors: Moreno, L, Lopez-Urbina, M.T., Farias, C, Domingue, G, Donadeu, M, Dungu, B, Garcia, H.H., Gomez-Puerta, L.A., Lanusse, C, Gonzalez, A.E.

Abstract

Oxfendazole (OFZ) is efficacious for porcine cysticercosis at 30 mg/kg. OFZ is not registered to be used at this dose. The assessment of the OFZ and metabolites [(fenbendazole sulphone (FBZSO2), fenbendazole (FBZ)] plasma pharmacokinetic and tissue residue profiles after its oral administration to pigs and the withdrawal period for human consumption were reported.

This is an output from the ‘Global Alliance For Livestock Veterinary Medicines (GALVmed): Phase 2 – Protecting Livestock and Saving Human Lives’ programme

Citation

L Moreno, M.T. Lopez-Urbina, C. Farias, G. Domingue, M. Donadeu, B. Dungu, H.H. Garcia, L.A. Gomez-Puerta, C. Lanusse, A.E. Gonzalez. (2012); Food and Chemical Toxicology; (50)10, 3819–3825 https://doi.org/10.1016/j.fct.2012.07.023

Links

A high oxfendazole dose to control porcine cysticercosis: Pharmacokinetics and tissue residue profiles

Published 30 October 2012