Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease
To verify the in vivo efficacy of sulfoxide and sulfone fexinidazole metabolites following oral administration in a model of Chagas disease
Abstract
This study was designed to verify the in vivo efficacy of sulfoxide and sulfone fexinidazole metabolites following oral administration in a murine model of Chagas disease.
This study was funded by the Drugs for Neglected Diseases initiative (DNDi)
Citation
Bahia MT, Nascimento AF, Mazzeti AL, Marques LF, Gonçalves KR, Mota LW, Diniz LD, Caldas IS, Talvani A, Shackleford DM, Koltun M, Saunders J, White KL, Scandale I, Charman SA, Chatelain E. (2014) Antitrypanosomal Activity of Fexinidazole Metabolites, Potential New Drug Candidates for Chagas Disease. Antimicrobial Agents and Chemotheraphy. August 2014 vol. 58 no. 8 4362-4370 doi: 10.1128/AAC.02754-13