Association between Directly Observed Therapy and Treatment Outcomes in Multidrug-Resistant Tuberculosis
This is a Systematic Review and Meta-Analysis
Abstract
Multidrug-resistant tuberculosis (MDR-TB) represents a major obstacle towards successful TB control. Directly observed therapy (DOT) was recommended by the World Health Organisation to improve adherence and treatment outcomes of MDR-TB patients. However, the effectiveness of DOT on treatment outcomes of MDR-TB patients was mixed in previous studies.
The authors conducted this systematic review and meta-analysis to assess the association between DOT and treatment outcomes and to examine the impact of different DOT providers and DOT locations on successful treatment outcomes in MDR-TB patients.
This research is supported by the Department for International Development’s COMDIS–HSD Programme which is led by the University of Leeds
Citation
Jia Yin, Jinqiu Yuan, Yanhong Hu, Xiaolin Wei. Association between Directly Observed Therapy and Treatment Outcomes in Multidrug-Resistant Tuberculosis: A Systematic Review and Meta-Analysis. Public Library of Science (PLOS) One 2016; 11(3) doi: 10.1371/journal.pone.0150511