Disposition of artesunate and mefloquine after administration as FDC to adult Thai healthy volunteers and uncomplicated falciparum malaria patients.

• From: Department for International Development
• Published: 1 January 2008

• Country: Thailand
• Document Type: Conference Paper
• Theme: Health
• Authors: Olliaro, P., Nair, N., Kiechel, J.R., Navaratnam, V., Ramanathan, S., Vaillant, M., Looareesuwan, S., Mansor, S.

Abstract

A randomized controlled trial in both healthy Thai volunteers and Plasmodium falciparum malaria patients compared the pharmacokinetics of artesunate and mefloquine after administration of the new fixed dose artesunate-mefloquine formulation ASMQ, and the equivalent doses of the two drugs given separately. There were some differences in the pharmacokinetic profiles between the two products, but these are thought not to be biologically relevant. Exposure to both drugs was higher in patients than in healthy people.

Citation

Presentatation from: Scientific Symposium "Implementation of Artemisinin Combination Therapies (ACTs): Role of ASMQ". Rio de Janeiro, Brazil, 17 April 2008.

Links

Disposition of artesunate and mefloquine after administration as FDC to adult Thai healthy volunteers and uncomplicated falciparum malaria patients.

Published 1 January 2008