Evaluation of parameters impacting drug susceptibility in intracellular T. cruzi assay protocols

Trypanosoma cruzi assay protocols were evaluated to understand the parameters influencing drug susceptibility

From:
Department for International Development
Published
1 February 2017
Document Type:
Journal Article
Theme:
Health
Authors:
Yang, G, Lee, N, loset, J-R, No, JH

Abstract

In this study, different Trypanosoma cruzi assay protocols were evaluated in order to understand the key parameters influencing drug susceptibility. The assays compared in this study were an image-based intracellular T. cruzi assay quantified through an image-mining algorithm and an intracellular assay utilizing a β-galactosidase-expressing T. cruzi strain.

This research was supported by the Drugs for Neglected Diseases initiative (DNDi).

Citation

Yang, G., Lee, N., Ioset, J.-R., & No, J. H. (2017). Evaluation of Parameters Impacting Drug Susceptibility in Intracellular Trypanosoma cruzi Assay Protocols. Slas Discovery, 22(2), 125–134. http://doi.org/10.1177/1087057116673796

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Published 1 February 2017
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