Genes encoding two Theileria parva antigens recognized by CD8+ T-cells exhibit sequence diversity in South Sudanese cattle populations
But the majority of alleles are similar to the Muguga component of the live vaccine cocktail
Abstract
East Coast fever, an emerging disease of cattle in South Sudan, is transmitted by the tick, Rhipicephalus appendiculatus. Management of East Coast fever is mainly through using compounds that kill ticks and mites; however, ticks are increasingly developing resistance to these compounds. Use of these compounds is also unsustainable in the medium term, due to food safety concerns.
This article discusses the immunisation of cattle using the infection and treatment method (ITM) that is increasingly being employed for control in countries affected by East Coast fever
This work is partly funded by the UK Department for International Development, a core donor of the International Centre of Insect Physiology and Ecology.
Citation
Salih D.A., Pelle R., Mwacharo J.M., Njahira M.N., Marcellino W.L., Kiara H., Malak A.K., EL Hussein A.R., Bishop R. and Skilton R.A. (2017) Genes encoding two Theileria parva antigens recognized by CD8+ T-cells exhibit sequence diversity in South Sudanese cattle populations but the majority of alleles are similar to the Muguga component of the live vaccine cocktail. PLoS ONE 12, e0171426. doi: 0171410.0171371/journal.pone.0171426.