Human Leukocyte Antigen Variants B*44 and B*57 Are Consistently Favorable during Two Distinct Phases of Primary HIV-1 Infection in Sub-Saharan Africans with Several Viral Subtypes

• From: Department for International Development
• Published: 1 January 2011

• Document Type: Journal Article
• Theme: Health
• Authors: Allen, S., Kamali, A., Karita, E., Anzala, O., Gilmour, J., Price, M.A., Sanders, E.J., Amornkul, P.N., Lakhi, S., Cormier, E., Hunter, E., Jianming Tang, Kaslow, R.A., Prentice, H.A., Wei Song

Abstract

As part of an ongoing study of early human immunodeficiency virus type 1 (HIV-1) infection in sub-Saharan African countries, we have identified 134 seroconverters (SCs) with distinct acute phase (peak) and early chronic phase (set-point) viremia. SCs with class I human leukocyte antigen (HLA) variants B*44 and B*57 had much lower peak viral load (VL) than SCs without these variants (adjusted linear regression beta = –1.08 ± 0.26 log10 and –0.83 ± 0.27 log10, respectively, P

Citation

Journal of Virology (2011) [doi:10.1128/JVI.00439-11] Published online ahead of print, 29 June 2011

Links

Human Leukocyte Antigen Variants B44 and B57 Are Consistently Favorable during Two Distinct Phases of Primary HIV-1 Infection in Sub-Saharan Africans with Several Viral Subtypes

Published 1 January 2011