Investigating the meat pathway as a source of human nontyphoidal Salmonella bloodstream infections and diarrhea in East Africa
This study collected cattle, goat, and poultry meat pathway samples in Tanzania and isolated Salmonella using standard methods
Abstract
Salmonella Enteritidis and Salmonella Typhimurium are major causes of bloodstream infection and diarrheal disease in East Africa. Sources of human infection, including the role of the meat pathway, are poorly understood.
The researchers collected cattle, goat, and poultry meat pathway samples from December 2015 through August 2017 in Tanzania and isolated Salmonella using standard methods. Meat pathway isolates were compared with nontyphoidal serovars of Salmonella enterica (NTS) isolated from persons with bloodstream infections and diarrheal disease from 2007 through 2017 from Kenya by core genome multi-locus sequence typing (cgMLST). Isolates were characterized for antimicrobial resistance, virulence genes, and diversity.
This is a publication arising from the Zoonoses and Emerging Livestock Systems (ZELS) programme.
Citation
Crump J, Thomas K, Benschop J, Knox M, Wilkinson D, Midwinter A, Munyua P, Ochieng J, Bigogo G, Verani J, Widdowson M, Prinsen G, Cleaveland S, Karimuribo E, Kazwala R, Mmbaga B, Swai E, French N, Zadoks R (2020). Investigating the meat pathway as a source of human nontyphoidal Salmonella bloodstream infections and diarrhea in East Africa. Clin Infect Dis. 10:ciaa1153.