Molecular detection and typing of pathogenic Leptospira in febrile patients
And phylogenetic comparison with Leptospira detected among animals in Tanzania.
Abstract
This study aimed to characterize the genetic diversity of human Leptospira infection in northern Tanzania and to infer possible sources of human infection. We applied direct pathogen detection methods including culture and NAAT to detect Leptospira infection and determine the infecting Leptospira species among febrile patients in northern Tanzania. We then used sequence-based analysis of the secY gene to compare pathogenic Leptospira genotypes detected in patients with those previously reported in animals in Tanzania to advance our understanding of the relationship between human and animal Leptospira infection.
This is a publication arising from the Zoonoses and Emerging Livestock Systems (ZELS) programme.
Citation
Allan K, Maze M, Galloway R, Rubach M, Biggs H, Halliday J, Cleaveland S, Saganda W, Lwezaula B, Kazwala R, Mmbaga B, Maro V, Crump J (2020). Molecular detection and typing of pathogenic Leptospira in febrile patients and phylogenetic comparison with Leptospira detected among animals in Tanzania. Am J Trop Med Hyg. 103:1427-1434.