Safety, efficacy, tolerability and first population pharmacokinetic study on fixed-dose artesunate/amodiaquine combination versus combined loose drugs for uncomplicated malaria in Kenyan adults.
Abstract
This study of 50 patients in Kisumu, Kenya, indicated that both the co-packaged drug combination and the new fixed-dose one were highly effective for the treatment of acute uncomplicated Plasmodium falciparum malaria, that they were both well tolerated, and that the pharmacokinetic parameters of amodiaquine and its active metabolite desethylamodiaquine are similar to those previously published, including in children, but elimination half-life of AQ was longer.
Citation
Presentation from American Society of Tropical Medicine and Hygiene 58th Annual Meeting, Washington, DC, USA, 18-22 November 2009.
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Published 1 January 2009