The control of East Coast fever of cattle by live parasite vaccination: A science-to-impact narrative
This paper chronicles the development of a live vaccine against EastCoast fever, a tick-borne disease of cattle caused by Theileria parva
Abstract
There is an increasing interest in determining the impact of vaccine technologies developed using public fundingtargeted at international development, and understanding the factors and ingredients which contribute to thesuccess and impacts of such vaccines.
This paper chronicles the development of a live vaccine against EastCoast fever, a tick-borne disease of cattle caused by Theileria parva. The paper describes the technological innovation,commonly known as infection-and-treatment, which was developed some 40 years ago, explores the institutionalsettings in which the vaccinewas developed and refined, and discusses the political dynamics of bothduring the decades from first development to field deployment and impacts. The paper also analyses the directand indirect indicators of success of ITM and the many qualifiers of these, the impacts that the emerging technologyhas had, both in positive and negative terms, and maps the key contributors and milestones onthe research-to-impact pathway
This is an output from the ‘Global Alliance For Livestock Veterinary Medicines (GALVmed): Phase 2 – Protecting Livestock and Saving Human Lives’ programme
Citation
B.D. Perry (2016) The control of East Coast fever of cattle by live parasite vaccination: A science-to-impact narrative. One Health; 2; 103-114 https://doi.org/10.1016/j.onehlt.2016.07.002