The ring vaccination trial

A novel cluster randomised controlled trial design to evaluate vaccine efficacy and effectiveness during outbreaks, with special reference to Ebola

• From: Foreign, Commonwealth & Development Office
• Published: 1 July 2015

• Document Type: Journal Article
• Theme: Health
• Authors: Henao-Restrepo, A.M.

Abstract

A World Health Organization expert meeting on Ebola vaccines proposed urgent safety and efficacy studies in response to the outbreak in West Africa. One approach to communicable disease control is ring vaccination of individuals at high risk of infection due to their social or geographical connection to a known case. This paper describes the protocol for a novel cluster randomised controlled trial design which uses ring vaccination.

This research was supported by the Research for Health in Humanitarian Crises (R2HC) Programme

Citation

Henao-Restrepo, Ana Maria. The ring vaccination trial: a novel cluster randomised controlled trial design to evaluate vaccine efficacy and effectiveness during outbreaks, with special reference to Ebola. BMJ 2015;351:h3740

Link

The ring vaccination trial : a novel cluster randomised controlled trial design to evaluate vaccine efficacy and effectiveness during outbreaks, with special reference to Ebola

Published 1 July 2015