Therapeutic vaccination (p24-VLP) of patients with advanced HIV-1 infection in the pre-HAART era does not alter CD4 cell decline

• From: Department for International Development
• Published: 1 January 2001

• Country: United Kingdom
• Document Type: Journal Article
• Theme: Health
• Authors: Smith, D., Weber, J., Gow, I., Colebunders, R., Weller, I., Tchamouroff, S., Boag, F., Hales, G., Adams, S., Patou, G., Cooper, D.A.

Abstract

In a randomized placebo controlled trial 304 HIV infected patients with CD4 cell counts below 350 cells/µL received monthly therapeutic vaccination for 6 months with: alum placebo (Group I, n = 102), p24-VLP 500 µg (Group II, n = 101) or p24-VLP 1000 µg (Group III, n = 101). Over one year the average change in CD4 cell count did not differ significantly between groups (–32, –40 and –52 cells per μL respectively). There was also no difference between groups in progression to CDC catagory B or C events, or in adverse events. Therapeutic vaccination with p24-VLP does not affect CD4 cell decline in patients with advanced HIV infection.

Citation

HIV Medicine (2001)Volume 2 Issue 4, Pages 272 - 275 [doi:10.1046/j.1468-1293.2001.00080.x]

Links

Therapeutic vaccination (p24-VLP) of patients with advanced HIV-1 infection in the pre-HAART era does not alter CD4 cell decline

Published 1 January 2001