Non-tech summaries 2016: projects on cancer
Projects granted during 2016 that have a primary purpose of translational and applied research - human cancer.
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This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2016 with a primary purpose of translational and applied research - human cancer.
The following projects were granted:
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gene transfer to rodents to test for adverse effects and correct disease (gene therapy, vectors, cancer, friedreich ataxia.)
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evaluation of novel anticancer agents (evaluation, novel, anticancer, agents)
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regulatory mechanisms in normal haematopoiesis (stem cells, haematopoiesis, leukaemia)
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development of new biological anticancer agents (cancer, virotherapy, targeted, biologic)
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evaluating new cancer therapies (lung cancer models, drug discovery)
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thermosensitive nanoparticles for cancer therapy (cancer treatment, drug development, liposomes, theranostics)
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mouse models of pancreatic cancer and therapy (pancreatic cancer, treatment, tumour stroma)
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anticancer drug discovery and target validation (anticancer, drug, discovery, target, validation)
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modelling bone-tumour interactions in metastasis (metastasis, breast/prostate cancer, myeloma, bone)
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novel biologicals for tumour immunotherapy (tumour immunotherapy; antibodies; adjuvants; targeted delivery)
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signal transduction in lung cancer pathogenesis (lung, cancer, autophagy, NF-κB, therapy)
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molecular imaging in cancer (molecular, imaging, cancer)
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development of new anticancer therapies (cancer, drugs, translation, biomarkers)
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mouse models of tumour growth and progression (cancer, metastasis, therapy, transplantation)
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in vivo imaging in cancer models (imaging, cancer, diagnosis, therapy)
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cancer therapy-efficacy licence (oncology, tumour, efficacy, pharmacodynamic)
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understanding and targeting the drivers of malignancy (cancer, prevention, treatment, metastasis)
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regulation of normal and malignant blood cells (stem cell, leukaemia, microenvironment, niche, self- renewal)
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oncolytic hsv as an anti –cancer therapy (oncolytic , cancer therapy)
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stem cell function in tissue regeneration, diabetes and cancer (stem cells, cancer, diabetes)
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modelling cancer predisposition by BRCA2 mutations (cancer; genetic alteration; pancreatic cancer)
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genetic analysis of tumour development (cancer, tumour, inflammation, therapy, imaging)
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tumour models for therapy of advanced cancers (tumour, metastasis, novel drugs, imaging)
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understanding inflammation, fibrosis and cancer (scarring, cancer, drugs)
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signalling pathways in cancer, inflammation, and metabolism (NF-κB, cancer, therapy, inflammation, metabolism)
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platelets and cardioprotection in cancer (platelets, cancer, cardio-toxicity, metastasis)
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oncology models (oncology, immunology, therapeutics)
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haematopoietic and leukaemia stem cell regulation (haematopoiesis; stem cells; leukaemia; lymphoma; leukaemia stem cells; novel therapy)
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novel strategies to target cancer (cancer, microenvironment, immunotherapy)
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engineered mice for gene function analysis (cancer, gene function, mouse, embryonic stem cells, embryonic development, developmental defect)
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studying the origins of cancers from stem cells (paediatric, adult, epithelial, cancer, biology)
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xenopus as a model for development and drug discovery (xenopus, developmental biology, cancer, stem cell biology)
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hypoxia and angiogenesis in cancer therapy (hypoxia, angiogenesis, cancer)
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mechanisms of metastasis (metastasis, myeloid cells, coagulation, extracellular matrix)
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induction of anti-tumour immunity (cancer, white cells, immune-therapy)
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modelling cancer biology and therapy in mouse (breast mammary cancer metastasis xenograft)
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establishment of patient derived xenografts from biopsy samples (cancer, tumour, biopsy, tissue generation)
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pancreatic cancer: biology and therapy (pancreatic cancer, pancreatitis, therapeutic targets)
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colorectal cancer initiation and progression (colorectal, cancer, RNA, genes)
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model systems to improve cancer immunotherapy (cancer, immotherapy, mouse)
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implantable microsystems for cancer therapy
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study and manipulation of immune-regulatory receptors to improve cancer therapeutics (cancer, immunology, immunotherapy, checkpoint)
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preclinical evaluation of cancer therapeutics (cancer, chemotherapy, immune-oncology)
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personalised tumour graft (tumour, human, personalised)
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assessment of novel cancer therapeutics (tolerability, pharmacokinetics, cancer, mouse, rat)
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enhancement of targeted radiotherapy of cancer (targeted, radiotherapy)
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the molecular basis of lymphoma and leukaemia (lymphoma, leukaemia, mouse models)
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pre-clinical assessment of new anticancer agents (oncolytic virus, immustimulation, vaccine, combination treatment, anti-cancer agent)
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analysing cancer: immune cell interactions involved in metastasis (cancer, imagine, animal models, immune system, cell signalling)
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generating new mouse models of human cancer (cancer, model, transgenic)
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skin cancer survival in the aging population (melanoma, microenvironment, squamous cell carcinoma, aging)
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mouse models for tumour stem cells and anti-tumour efficacy studies (cancer, brain tumours, tumour growth, invasion)
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developing an ocular melanoma model for drug discovery (ocular melanoma, uveal melanoma, patient derived xenograft MEK)
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adoptive T cell therapy for cancer (cancer, T lymphocytes, T-cell receptor, immunotherapy, adoptive therapy)
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drug evaluation in pre-clinical oncology models (cancer, pre-clinical, efficacy, models, imaging)
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cellular immunotherapy of disease (gene-modified immune cells, tumour immunity)
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MYB proteins and myeloid disease susceptibility (stem cells, bone marrow, blood cells, leukaemia, ageing)
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interrogating the immunology of cancer and the development of cancer therapeutics (vaccine, therapeutics, cancer, immune cells)
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pancreatic cancer – improving our understanding and therapeutic options (pancreatic cancer, therapeutic, genotype/phenotype)
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vaccine development and immunotherapy (cancer therapy, vaccine, therapeutic antibody)
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regulation of tumour growth and metastasis by sodium channels (antiepileptic drugs, breast cancer, invasion, metastasis, sodium channels)
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immune cell mechanisms in cancer and infection (infection, cancer, immunology)
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immune and biological therapies for cancer (cancer, virus, immune system)
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modelling a gene family in human disease (cancer, heart, skin, inflammation)
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cancer therapy – enabling licence (tolerability, pharmacokinetics, tumour, surrogate)
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sarcoma, bone niche, microenvironment and therapy (cancer, microenvironment, biomarkers, therapy)
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hematopoiesis in development, aging and malignancy (stem cells, development, leukemia, aging, transplantation)
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in vivo evaluation of enadenotucirev derived viruses (oncolytic, adenovirus, cancer, immunotherapy)
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normal and leukemic blood cell development (stem cells, infant leukaemia, transplantation)
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regeneration/neoplasia of nervous system and muscle (stem cells, organ regeneration, brain tumour)