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Non-tech summaries 2016: projects on immune system

Projects granted during 2016 that have a primary purpose of basic research, immune system.

• From: Home Office
• Published: 22 December 2017

Documents

Non-technical summaries: projects granted in 2016, volume 7

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Details

This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2016 with a primary purpose of basic research, immune system

The following projects were granted:

• immunity against bacterial and paediatric diseases (vaccines, infectious diseases, paediatrics, bacteria)

• poxvirus virulence and immunogenicity (immunisation, vaccines, immunology, virus virulence, protein function)

• development and function of the immune system (lymphocyte, infection, autoimmunity, signalling)

• genetic and physical control of B cell activation (antibody responses, activation of immune cells, signalling, endocytosis)

• immunity to ruminant endo- and ecto-parasites (vaccine parasite sheep cattle)

• salmonella pathogenesis during asymptomatic malaria (malaria salmonella anaemia neutrophil bacteraemia)

• establishing model for zika infection (zika virus, pathology, immunity)

• explore the mechanisms of persistence of tertiary lymphoid organs (TLOs) and the relationship with secondary lymphoid organs (tertiary lymphoid structures, salivary glands, immune response, inflammation)

• inflammatory responses to infection and insult (inflammation, viral infection, immunology)

• regulation of immune responses (immunity, cell development)

• bone marrow transplantation: biology and therapy (GVHD, GVT, tumour, leukaemia)

• identifying new malaria intervention strategies (malaria, plasmodium, genetically modified parasite)

• mammalian gene control mechanisms and disease (gene regulation, chromatin, triplet repeat disorders, position effect variegation, epigenetics)

• yô T cells and body surface immunity (yö T-cell immune challenge)

• immunological memory in transgenic mice (T lymphocyte, virus, tumour, immunity)

• immune regulation, metabolism and tissue integrity (T cells; environment, autoimmunity, mucosal immunity, metabolism)

• ZBTB proteins in lymphocyte development (lymphoma)

• immune cell regulation of epithelial damage and repair (epithelial, repair, T cells, auto-inflammation)

• molecular mechanisms of T cell mediated immune responses (immune response, autoimmunity, egr, viral infection, tumour)

• lymphocyte development and antibody repertoire formation (fighting infection, antibodies, ageing, immune response, white blood cells)

• DNA double-strand break repair, immunity & cancer (DNA repair, cancer, immune system)

• interactions between mast cells and helminths in inflammatory disease (mast cells, helminths, diabetes, arthritis, cardiovascular disease)

• complement properdin in immunity and inflammation (properdin, tumour, diet, stimulation)

• inflammation, cell death and cancer (inflammation, immunity, cancer)

• translation of the immunological synapse (immunological synapse, tolerogenic DCs, central tolerance, atopic dermatitis, original antigenic sin)

• immune activation in health and disease (immunity, adjuvants, vaccines, allergy, hypersensitivity)

• mouse models of chronic inflammatory diseases (cancer, infections, autoimmune disease, pain)

• tregs in lymphopaenia associated autoimmunity (lymphopaenia, autoimmunity, immunotherapy)

Published 22 December 2017