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Non-tech. summaries 2014: projects on the cardiovascular system

Projects granted during 2014 that have a primary purpose of basic research into the cardiovascular, blood and lymphatic system.

• From: Home Office
• Published: 25 April 2016

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Non-technical summaries: projects granted in 2014, volume 19

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Details

This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2014 with a primary purpose of basic research into the cardiovascular, blood and lymphatic system.

The following projects were granted:

• neural regulation of cardiovascular function (blood pressure, sympathetic, hypertension, homeostasis, autonomic nervous system)
• neural control of myocardial excitability in cardiovascular disease (heart, brain, autonomic nervous system, free radical, cyclic nucleotides)
• characterizing how lipids regulate cardiovascular disease and bleeding (atherosclerosis, lipids, bleeding)
• therapeutic neovascularisation for ischemic disease (neovascularisation, Ischemia, cardiovascular disease)
• molecular regulation of heart development (mouse, embryo, development, heart, vasculature)
• prevention of organ injury following cardiac surgery (cardiac surgery, organ failure, transfusion)
• interplay between oxygen and iron in hypoxia-induced pathology (iron, hypoxia, heart, muscle, placenta)
• inflammation and atherosclerosis (inflammation, atherosclerosis, collar, disease, therapy)
• provision of biological materials (blood, macaque, in-vitro)
• thromboinflammation in thrombosis in veins (thrombosis, inflammation, mast cells, T-cells, platelets)
• genetics of cardiovascular development and function (heart development, heart disease, genetics)
• studies on the mechanisms of atherosclerosis (accelerated atherosclerosis, restenosis, hypercholesterolaemia)
• regulation of haematopoietic development (Haematopoiesis, Angiogenesis, Embryogenesis, Leukaemia)
• production of antibodies for research purposes (production of antibodies for research)
• regulation of heart development in vertebrates (heart, cardiogenesis, morphology, non-compaction)
• endothelial dysfunction in pulmonary hypertension (vessel wall thickening, lung, hypoxia, inflammation)
• de novo generation of haematopoietic stem cells (blood, stem cells, genetic program, haematopoiesis, transplantation)
• antibody production (antibodies, immunisation)
• regulation of blood vessel maintenance and repair (blood vessels, heart attack, aneurysm, cardiovascular disease)
• adaptive mechanisms of the ischaemic myocardium (myocardial infarction, gene-modified animals, redox, cardiac remodelling, heart failure)
• characterising and inhibiting vascular disturbances (microcirculation, stem cells, inflammation)
• regenerative capacity of skeletal and cardiac muscle (cardiac stem cells; skeletal muscle stem cells; repair, regeneration; myocardium)
• regulation and mechanism of platelet activation by GPVI and CLEC-2 (platelets, signal-transduction, haemostasis, vascular-integrity)
• cardiovascular effects of uraemia (kidney disease, heart failure, uraemia, diabetes)
• systems biology of cardiac biophysics (heart rhythm, infarction, ablation, fibrosis)
• the regulation and role of protein kinases in the heart (heart failure, the failing heart, heart disease, protein kinases, phosphorylation)
• mouse models of cardiovascular development and disease (heart, cardiogenesis, CHD, mouse models 4)
• control of early heart development in vertebrates (heart, embryo, frog)
• molecular mechanisms of development (angiogenesis, inflammation, drug screening, molecular targets)

Published 25 April 2016