Non-tech summaries 2016: projects on cardiovascular disorders
Projects granted during 2016 that have a primary purpose of translational applied research - human cardiovascular disorders.
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This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2016 with a primary purpose of translational applied research - human cardiovascular disorders.
The following projects were granted:
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analysing signalling gene function in the heart (heart, electrophysiology, hypertrophy, arrhythmias)
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mechanisms of innate immunity in cardiovascular disease (heart disease, immune system)
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prevention of chronic heart failure (heart failure, myocardial infarction, diabetes, hypercholesterinaemia)
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genetic and bioenergetic determinants of cardiac arrhythmias (arrhythmias, heart disease, sudden death, genetics)
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autonomic control of the cardiovascular system (cardiovascular disease, autonomic control)
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the effects of myocardial infarction (myocardial infarction)
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preclinical therapies for pulmonary hypertension (cardiovascular, pulmonary, genetics, therapy)
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pathophysiology of the cardiovascular system (metabolic syndrome; obesity; heart function; atherosclerosis)
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comparative cardiovascular homeostasis (transgenics; hypertension; metabolism; kidney)
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mechanisms of progressive cardiac dysfunction (heart failure, hypertrophy, cardiac remodelling)
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pathophysiology of heart failure (heart failure, calcium, β-adrenergic, ultrastructure)
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cardiac injury, repair, regeneration & remodelling (heart attack, drug therapy, heart failure)
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dietary vascular protection in utero and stroke (stroke, obesity, pregnancy, risk, diabetes)
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mechanisms of thrombosis and atherosclerosis (macrophages, endothelial cells, inflammation, atherosclerosis, thrombosis, cardiovascular disease)
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investigating the genetics of cardiovascular disease (hypertension, organ-damage, rats, mice, genetics)
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investigating a novel treatment for heart failure (perhexiline, metabolism, hypertrophy, heart failure)
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small animal models of cardiovascular disease (ischaemia, therapy, cardiovascular disease)
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regulation of thrombosis and haemostasis and its influence on cardiovascular diseases (clot, thrombosis, stroke, atherosclerosis, vessel wall)
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pathogenesis and therapy of vascular diseases (atherosclerosis; aneurysm; angiogenesis; cell therapy; cardiovascular diseases intervention.)
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rodent models of arteriosclerosis (arteriosclerosis, stem cells, endothelial cells, vessel graft)
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role of nitric oxide and reactive oxygen species in cardiac function (nitric oxide, reactive oxygen species, heart failure, diabetes, atrial fibrillation)
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rodent models of pulmonary hypertension and associated co-morbidities (pulmonary hypertension, pulmonary vascular remodelling, right heart failure)
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vascular protective genes in angiogenesis (vascular, preeclampsia, hydrogen sulphide, heme oxygenase, pregnancy)
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myocardial infarction and heart failure (heart, failure, infarction, protection, injury)
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angiogenesis, microcirculation and microenvironment (angiogenesis, microcirculation, tumour growth, wound-healing, vascular-targeted)
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protecting and repairing the diseased heart (heart attack, cardiac surgery, ischemia reperfusion injury)
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factors affecting valve development and disease (veins, lymphatics, heart)
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studies of complex genetic traits in rats (rat, cardiovascular, metabolic, kidney genetics)
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mechanistic studies in pre-clinical stroke/small vessel disease (stroke, small vessel disease, hypertension, rats, mice)
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understanding and treating cardiovascular disease (cardiovascular development, heart repair)
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the molecular basis of cardio-metabolic disease (diabetes, cardiovascular disease, insulin resistance, insulin-like growth factors, atherosclerosis)
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myocardial infarction (heart attack, vascular dysfunction, nitrite, nitric oxide, perhexiline)
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calcium-permeable channels and their associated mechanisms and therapeutic potential (blood vessel, cardiovascular disease, cancer, diabetes, calcium channels)
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improving minimally invasive treatment of coronary artery disease (coronary, artery, atherosclerosis, angioplasty, stents)
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targeting the immune response in cardiovascular diseases (atherosclerosis; restenosis; aneurysm; myocardial infarction; stroke)
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innovative treatments for heart failure (heart failure, stem cell therapy, gene therapy, drug therapy)
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ischaemia-reperfusion injury and shock (ischaemia, shock, kidney, haemorrhage, heart research, trauma)
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the long-term effects of prenatal hypoxia on cardiomyocyte function (programming, pre-natal hypoxia, cardiac, mitochondria, myocyte)