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Non-tech summaries 2016: projects on urogenital disorders

Projects granted during 2016 that have a primary purpose of translational research - human urogenital/reproductive disorders.

• From: Home Office
• Published: 21 December 2017

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Non-technical summaries: projects granted in 2016, volume 24

PDF, 453 KB, 63 pages

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Details

This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2016 with a primary purpose of translational research - human urogenital/reproductive disorders.

The following projects were granted:

• the pathophysiology of endometriosis (endometrium, endometriosis, macrophage, nerves)

• mechanisms of uterine physiology and pathology (endometrium, bleeding, menstruation, fibroids)

• molecular factors affecting sperm production and function (fertility, reproduction, sperm, sex ratio)

• understanding and treating pregnancy related disorders (pregnancy, preterm labour, parturition, uterus, cervix)

• vitamin D and immune function (vitamin d, colon, pregnancy, placenta, inflammation)

• precursor cell therapies for kidney diseases (kidney cell mouse therapy scanning)

• improving organ function in kidney transplantation (renal, transplant, therapy, regenerative)

• rodent models of kidney disease (rodent models, kidney disease)

• the effects of aging on tissue injury and repair (kidney, acute injury, chronic fibrosis)

• endometrial function and associated disorders (uterus, steroid, inflammation, repair, endometriosis)

• optimising ovarian tissue transplantation by improving vascularisation (fertility preservation, xenografting, nude mouse, human ovarian tissue, transplantation)

• mechanism of bladder cancer and translation (Cre-LoxP, carcinogen, FGFR3, CXCR2, cell free DNA)

• optimisation of drug efficacy and safety in bladder cancer (cancer, chemotherapy, toxicity)

• pkcα and vascular calcification in kidney dysfunction (PKCα, vascular calcification, chronic kidney disease)

• decellularised biomaterials for homologous use in urinary bladder auto-augmentation (biomaterial, urinary tract, detrusorotomy, bladder)

• modelling therapies for renal malformations (kidney, ureter, bladder, malformation, therapy)

• the causes and treatment of rejection of kidney (alloimunity, inflammation, tissue scarring, kidney disease)

• biochemical pathways in renal fibrosis (renal, kidney, fibrosis, therapeutic)

• regenerative medicine therapy for renal injury (regenerative medicine, cell therapy, kidney, injury)

Published 21 December 2017